Inhibitors | Comment | Organism | Structure |
---|---|---|---|
alpha-difluoromethylornithine | irreversible and specific inhibitor of ODC | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
C2C12 cell | - |
Mus musculus | - |
muscle | - |
Mus musculus | - |
myoblast | Odc1 is expressed predominantly in proliferating myoblasts | Mus musculus | - |
myotube | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-ornithine | - |
Mus musculus | putrescine + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ODC | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | Odc1 expression is decreased more than 60% in muscle from male muscle-specific androgen receptor knockout mice | down |
Mus musculus | ornithine decarboxylase is upregulated by the androgen receptor in skeletal muscle. Muscle of adult male mice expresses high levels of Odc1 compared with age-matched females and younger males. Dihydrotestosterone increases Odc1 levels 2.7 and 1.6fold in skeletal muscle cell myoblasts after 12 and 24 h of treatment, respectively | up |
General Information | Comment | Organism |
---|---|---|
malfunction | inhibition of ODC activity in C2C12 myoblasts by alpha-difluoromethylornithine decreases myoblast number by 40% and 66% following 48 and 72 h of treatment, respectively | Mus musculus |
metabolism | ODC is the rate-limiting enzyme in polyamine biosynthesis | Mus musculus |
physiological function | ornithine decarboxylase promotes myoblast proliferation and delays differentiation. Overexpression of Odc1 in C2C12 myoblasts results in a 27% increase in cell number vs. control when cells are grown under differentiation conditions for 96 h | Mus musculus |