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Literature summary for 4.1.1.17 extracted from

  • Lee, N.K.; Skinner, J.P.; Zajac, J.D.; MacLean, H.E.
    Ornithine decarboxylase is upregulated by the androgen receptor in skeletal muscle and regulates myoblast proliferation (2011), Am. J. Physiol. Endocrinol. Metab., 301, E172-E179.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
alpha-difluoromethylornithine irreversible and specific inhibitor of ODC Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
C2C12 cell
-
Mus musculus
-
muscle
-
Mus musculus
-
myoblast Odc1 is expressed predominantly in proliferating myoblasts Mus musculus
-
myotube
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-ornithine
-
Mus musculus putrescine + CO2
-
?

Synonyms

Synonyms Comment Organism
ODC
-
Mus musculus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
Mus musculus

Expression

Organism Comment Expression
Mus musculus Odc1 expression is decreased more than 60% in muscle from male muscle-specific androgen receptor knockout mice down
Mus musculus ornithine decarboxylase is upregulated by the androgen receptor in skeletal muscle. Muscle of adult male mice expresses high levels of Odc1 compared with age-matched females and younger males. Dihydrotestosterone increases Odc1 levels 2.7 and 1.6fold in skeletal muscle cell myoblasts after 12 and 24 h of treatment, respectively up

General Information

General Information Comment Organism
malfunction inhibition of ODC activity in C2C12 myoblasts by alpha-difluoromethylornithine decreases myoblast number by 40% and 66% following 48 and 72 h of treatment, respectively Mus musculus
metabolism ODC is the rate-limiting enzyme in polyamine biosynthesis Mus musculus
physiological function ornithine decarboxylase promotes myoblast proliferation and delays differentiation. Overexpression of Odc1 in C2C12 myoblasts results in a 27% increase in cell number vs. control when cells are grown under differentiation conditions for 96 h Mus musculus