Literature summary for 4.1.1.17 extracted from

Ivanov, I.P.; Firth, A.E.; Atkins, J.F.
Recurrent emergence of catalytically inactive ornithine decarboxylase homologous forms that likely have regulatory function (2010), J. Mol. Evol., 70, 289-302.

Activating Compound

Activating Compound	Comment	Organism
additional information	antizyme inhibitors are homologs of ODC that have lost their decarboxylation activity but have retained their ability to bind the ODC inhibitor antizyme, in most cases even more tightly than ODC	Gallus gallus
additional information	antizyme inhibitors are homologs of ODC that have lost their decarboxylation activity but have retained their ability to bind the ODC inhibitor antizyme, in most cases even more tightly than ODC	Drosophila melanogaster
additional information	antizyme inhibitors are homologs of ODC that have lost their decarboxylation activity but have retained their ability to bind the ODC inhibitor antizyme, in most cases even more tightly than ODC	Mus musculus
additional information	antizyme inhibitors are homologs of ODC that have lost their decarboxylation activity but have retained their ability to bind the ODC inhibitor antizyme, in most cases even more tightly than ODC	Homo sapiens
additional information	antizyme inhibitors are homologs of ODC that have lost their decarboxylation activity but have retained their ability to bind the ODC inhibitor antizyme, in most cases even more tightly than ODC	Rattus norvegicus
additional information	antizyme inhibitors are homologs of ODC that have lost their decarboxylation activity but have retained their ability to bind the ODC inhibitor antizyme, in most cases even more tightly than ODC	Bos taurus
additional information	antizyme inhibitors are homologs of ODC that have lost their decarboxylation activity but have retained their ability to bind the ODC inhibitor antizyme, in most cases even more tightly than ODC	Neurospora crassa
additional information	antizyme inhibitors are homologs of ODC that have lost their decarboxylation activity but have retained their ability to bind the ODC inhibitor antizyme, in most cases even more tightly than ODC	Trypanosoma brucei
additional information	antizyme inhibitors are homologs of ODC that have lost their decarboxylation activity but have retained their ability to bind the ODC inhibitor antizyme, in most cases even more tightly than ODC	Dictyostelium discoideum
additional information	antizyme inhibitors are homologs of ODC that have lost their decarboxylation activity but have retained their ability to bind the ODC inhibitor antizyme, in most cases even more tightly than ODC	Canis lupus familiaris
additional information	antizyme inhibitors are homologs of ODC that have lost their decarboxylation activity but have retained their ability to bind the ODC inhibitor antizyme, in most cases even more tightly than ODC	Xenopus laevis
additional information	antizyme inhibitors are homologs of ODC that have lost their decarboxylation activity but have retained their ability to bind the ODC inhibitor antizyme, in most cases even more tightly than ODC	Caenorhabditis elegans
additional information	antizyme inhibitors are homologs of ODC that have lost their decarboxylation activity but have retained their ability to bind the ODC inhibitor antizyme, in most cases even more tightly than ODC	Meyerozyma guilliermondii
additional information	antizyme inhibitors are homologs of ODC that have lost their decarboxylation activity but have retained their ability to bind the ODC inhibitor antizyme, in most cases even more tightly than ODC	Aedes aegypti
additional information	antizyme inhibitors are homologs of ODC that have lost their decarboxylation activity but have retained their ability to bind the ODC inhibitor antizyme, in most cases even more tightly than ODC	Aspergillus fischeri
additional information	antizyme inhibitors are homologs of ODC that have lost their decarboxylation activity but have retained their ability to bind the ODC inhibitor antizyme, in most cases even more tightly than ODC	Aspergillus terreus
additional information	antizyme inhibitors are homologs of ODC that have lost their decarboxylation activity but have retained their ability to bind the ODC inhibitor antizyme, in most cases even more tightly than ODC	Fusarium oxysporum
additional information	antizyme inhibitors are homologs of ODC that have lost their decarboxylation activity but have retained their ability to bind the ODC inhibitor antizyme, in most cases even more tightly than ODC	Fusarium verticillioides
additional information	antizyme inhibitors are homologs of ODC that have lost their decarboxylation activity but have retained their ability to bind the ODC inhibitor antizyme, in most cases even more tightly than ODC	Aspergillus clavatus
additional information	antizyme inhibitors are homologs of ODC that have lost their decarboxylation activity but have retained their ability to bind the ODC inhibitor antizyme, in most cases even more tightly than ODC	Aspergillus fumigatus
additional information	antizyme inhibitors are homologs of ODC that have lost their decarboxylation activity but have retained their ability to bind the ODC inhibitor antizyme, in most cases even more tightly than ODC	Ciona intestinalis
additional information	antizyme inhibitors are homologs of ODC that have lost their decarboxylation activity but have retained their ability to bind the ODC inhibitor antizyme, in most cases even more tightly than ODC	Branchiostoma floridae
additional information	antizyme inhibitors are homologs of ODC that have lost their decarboxylation activity but have retained their ability to bind the ODC inhibitor antizyme, in most cases even more tightly than ODC	Botrytis cinerea
additional information	antizyme inhibitors are homologs of ODC that have lost their decarboxylation activity but have retained their ability to bind the ODC inhibitor antizyme, in most cases even more tightly than ODC	Coccidioides immitis
additional information	antizyme inhibitors are homologs of ODC that have lost their decarboxylation activity but have retained their ability to bind the ODC inhibitor antizyme, in most cases even more tightly than ODC	Anopheles gambiae
additional information	antizyme inhibitors are homologs of ODC that have lost their decarboxylation activity but have retained their ability to bind the ODC inhibitor antizyme, in most cases even more tightly than ODC	Caenorhabditis briggsae
additional information	antizyme inhibitors are homologs of ODC that have lost their decarboxylation activity but have retained their ability to bind the ODC inhibitor antizyme, in most cases even more tightly than ODC	Culex pipiens
additional information	antizyme inhibitors are homologs of ODC that have lost their decarboxylation activity but have retained their ability to bind the ODC inhibitor antizyme, in most cases even more tightly than ODC	Ancylostoma ceylanicum
additional information	antizyme inhibitors are homologs of ODC that have lost their decarboxylation activity but have retained their ability to bind the ODC inhibitor antizyme, in most cases even more tightly than ODC	Takifugu rubripes
additional information	antizyme inhibitors are homologs of ODC that have lost their decarboxylation activity but have retained their ability to bind the ODC inhibitor antizyme, in most cases even more tightly than ODC	Petromyzon marinus
additional information	antizyme inhibitors are homologs of ODC that have lost their decarboxylation activity but have retained their ability to bind the ODC inhibitor antizyme, in most cases even more tightly than ODC	Parastagonospora nodorum
additional information	antizyme inhibitors are homologs of ODC that have lost their decarboxylation activity but have retained their ability to bind the ODC inhibitor antizyme, in most cases even more tightly than ODC	Uncinocarpus reesii
additional information	antizyme inhibitors are homologs of ODC that have lost their decarboxylation activity but have retained their ability to bind the ODC inhibitor antizyme, in most cases even more tightly than ODC	Hydra vulgaris
additional information	antizyme inhibitors are homologs of ODC that have lost their decarboxylation activity but have retained their ability to bind the ODC inhibitor antizyme, in most cases even more tightly than ODC	Tetraodon nigroviridis
additional information	antizyme inhibitors are homologs of ODC that have lost their decarboxylation activity but have retained their ability to bind the ODC inhibitor antizyme, in most cases even more tightly than ODC	Gasterosteus aculeatus
additional information	antizyme inhibitors are homologs of ODC that have lost their decarboxylation activity but have retained their ability to bind the ODC inhibitor antizyme, in most cases even more tightly than ODC	Dugesia japonica
additional information	antizyme inhibitors are homologs of ODC that have lost their decarboxylation activity but have retained their ability to bind the ODC inhibitor antizyme, in most cases even more tightly than ODC	Anolis carolinensis
additional information	antizyme inhibitors are homologs of ODC that have lost their decarboxylation activity but have retained their ability to bind the ODC inhibitor antizyme, in most cases even more tightly than ODC	Schmidtea mediterranea
additional information	antizyme inhibitors are homologs of ODC that have lost their decarboxylation activity but have retained their ability to bind the ODC inhibitor antizyme, in most cases even more tightly than ODC	Nasonia vitripennis

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.
L-ornithine	Gallus gallus	-	putrescine + CO2	-	?
L-ornithine	Drosophila melanogaster	-	putrescine + CO2	-	?
L-ornithine	Mus musculus	-	putrescine + CO2	-	?
L-ornithine	Homo sapiens	-	putrescine + CO2	-	?
L-ornithine	Rattus norvegicus	-	putrescine + CO2	-	?
L-ornithine	Bos taurus	-	putrescine + CO2	-	?
L-ornithine	Neurospora crassa	-	putrescine + CO2	-	?
L-ornithine	Trypanosoma brucei	-	putrescine + CO2	-	?
L-ornithine	Dictyostelium discoideum	-	putrescine + CO2	-	?
L-ornithine	Canis lupus familiaris	-	putrescine + CO2	-	?
L-ornithine	Xenopus laevis	-	putrescine + CO2	-	?
L-ornithine	Caenorhabditis elegans	-	putrescine + CO2	-	?
L-ornithine	Meyerozyma guilliermondii	-	putrescine + CO2	-	?
L-ornithine	Aedes aegypti	-	putrescine + CO2	-	?
L-ornithine	Aspergillus fischeri	-	putrescine + CO2	-	?
L-ornithine	Aspergillus terreus	-	putrescine + CO2	-	?
L-ornithine	Fusarium oxysporum	-	putrescine + CO2	-	?
L-ornithine	Fusarium verticillioides	-	putrescine + CO2	-	?
L-ornithine	Aspergillus clavatus	-	putrescine + CO2	-	?
L-ornithine	Aspergillus fumigatus	-	putrescine + CO2	-	?
L-ornithine	Ciona intestinalis	-	putrescine + CO2	-	?
L-ornithine	Branchiostoma floridae	-	putrescine + CO2	-	?
L-ornithine	Botrytis cinerea	-	putrescine + CO2	-	?
L-ornithine	Coccidioides immitis	-	putrescine + CO2	-	?
L-ornithine	Anopheles gambiae	-	putrescine + CO2	-	?
L-ornithine	Caenorhabditis briggsae	-	putrescine + CO2	-	?
L-ornithine	Culex pipiens	-	putrescine + CO2	-	?
L-ornithine	Ancylostoma ceylanicum	-	putrescine + CO2	-	?
L-ornithine	Takifugu rubripes	-	putrescine + CO2	-	?
L-ornithine	Petromyzon marinus	-	putrescine + CO2	-	?
L-ornithine	Parastagonospora nodorum	-	putrescine + CO2	-	?
L-ornithine	Uncinocarpus reesii	-	putrescine + CO2	-	?
L-ornithine	Hydra vulgaris	-	putrescine + CO2	-	?
L-ornithine	Tetraodon nigroviridis	-	putrescine + CO2	-	?
L-ornithine	Gasterosteus aculeatus	-	putrescine + CO2	-	?
L-ornithine	Dugesia japonica	-	putrescine + CO2	-	?
L-ornithine	Anolis carolinensis	-	putrescine + CO2	-	?
L-ornithine	Schmidtea mediterranea	-	putrescine + CO2	-	?
L-ornithine	Nasonia vitripennis	-	putrescine + CO2	-	?

Organism

Organism	UniProt	Comment	Textmining
Aedes aegypti	-	-	-
Ancylostoma ceylanicum	-	-	-
Anolis carolinensis	-	-	-
Anopheles gambiae	-	-	-
Aspergillus clavatus	-	-	-
Aspergillus fischeri	-	-	-
Aspergillus fumigatus	-	-	-
Aspergillus terreus	-	-	-
Bos taurus	-	-	-
Botrytis cinerea	-	-	-
Branchiostoma floridae	-	-	-
Caenorhabditis briggsae	-	-	-
Caenorhabditis elegans	-	-	-
Canis lupus familiaris	-	-	-
Ciona intestinalis	-	-	-
Coccidioides immitis	-	-	-
Culex pipiens	-	-	-
Dictyostelium discoideum	-	-	-
Drosophila melanogaster	-	-	-
Dugesia japonica	-	-	-
Fusarium oxysporum	-	-	-
Fusarium verticillioides	-	-	-
Gallus gallus	-	-	-
Gasterosteus aculeatus	-	-	-
Homo sapiens	-	-	-
Hydra vulgaris	-	-	-
Meyerozyma guilliermondii	-	-	-
Mus musculus	-	-	-
Nasonia vitripennis	-	-	-
Neurospora crassa	-	-	-
Parastagonospora nodorum	-	-	-
Petromyzon marinus	-	-	-
Rattus norvegicus	-	-	-
Schmidtea mediterranea	-	-	-
Takifugu rubripes	-	-	-
Tetraodon nigroviridis	-	-	-
Trypanosoma brucei	-	-	-
Uncinocarpus reesii	-	-	-
Xenopus laevis	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.
L-ornithine	-	Gallus gallus	putrescine + CO2	-	?
L-ornithine	-	Drosophila melanogaster	putrescine + CO2	-	?
L-ornithine	-	Mus musculus	putrescine + CO2	-	?
L-ornithine	-	Homo sapiens	putrescine + CO2	-	?
L-ornithine	-	Rattus norvegicus	putrescine + CO2	-	?
L-ornithine	-	Bos taurus	putrescine + CO2	-	?
L-ornithine	-	Neurospora crassa	putrescine + CO2	-	?
L-ornithine	-	Trypanosoma brucei	putrescine + CO2	-	?
L-ornithine	-	Dictyostelium discoideum	putrescine + CO2	-	?
L-ornithine	-	Canis lupus familiaris	putrescine + CO2	-	?
L-ornithine	-	Xenopus laevis	putrescine + CO2	-	?
L-ornithine	-	Caenorhabditis elegans	putrescine + CO2	-	?
L-ornithine	-	Meyerozyma guilliermondii	putrescine + CO2	-	?
L-ornithine	-	Aedes aegypti	putrescine + CO2	-	?
L-ornithine	-	Aspergillus fischeri	putrescine + CO2	-	?
L-ornithine	-	Aspergillus terreus	putrescine + CO2	-	?
L-ornithine	-	Fusarium oxysporum	putrescine + CO2	-	?
L-ornithine	-	Fusarium verticillioides	putrescine + CO2	-	?
L-ornithine	-	Aspergillus clavatus	putrescine + CO2	-	?
L-ornithine	-	Aspergillus fumigatus	putrescine + CO2	-	?
L-ornithine	-	Ciona intestinalis	putrescine + CO2	-	?
L-ornithine	-	Branchiostoma floridae	putrescine + CO2	-	?
L-ornithine	-	Botrytis cinerea	putrescine + CO2	-	?
L-ornithine	-	Coccidioides immitis	putrescine + CO2	-	?
L-ornithine	-	Anopheles gambiae	putrescine + CO2	-	?
L-ornithine	-	Caenorhabditis briggsae	putrescine + CO2	-	?
L-ornithine	-	Culex pipiens	putrescine + CO2	-	?
L-ornithine	-	Ancylostoma ceylanicum	putrescine + CO2	-	?
L-ornithine	-	Takifugu rubripes	putrescine + CO2	-	?
L-ornithine	-	Petromyzon marinus	putrescine + CO2	-	?
L-ornithine	-	Parastagonospora nodorum	putrescine + CO2	-	?
L-ornithine	-	Uncinocarpus reesii	putrescine + CO2	-	?
L-ornithine	-	Hydra vulgaris	putrescine + CO2	-	?
L-ornithine	-	Tetraodon nigroviridis	putrescine + CO2	-	?
L-ornithine	-	Gasterosteus aculeatus	putrescine + CO2	-	?
L-ornithine	-	Dugesia japonica	putrescine + CO2	-	?
L-ornithine	-	Anolis carolinensis	putrescine + CO2	-	?
L-ornithine	-	Schmidtea mediterranea	putrescine + CO2	-	?
L-ornithine	-	Nasonia vitripennis	putrescine + CO2	-	?

Synonyms

Synonyms	Comment	Organism
ODC	-	Gallus gallus
ODC	-	Drosophila melanogaster
ODC	-	Mus musculus
ODC	-	Homo sapiens
ODC	-	Rattus norvegicus
ODC	-	Bos taurus
ODC	-	Neurospora crassa
ODC	-	Trypanosoma brucei
ODC	-	Dictyostelium discoideum
ODC	-	Canis lupus familiaris
ODC	-	Xenopus laevis
ODC	-	Caenorhabditis elegans
ODC	-	Meyerozyma guilliermondii
ODC	-	Aedes aegypti
ODC	-	Aspergillus fischeri
ODC	-	Aspergillus terreus
ODC	-	Fusarium oxysporum
ODC	-	Fusarium verticillioides
ODC	-	Aspergillus clavatus
ODC	-	Aspergillus fumigatus
ODC	-	Ciona intestinalis
ODC	-	Branchiostoma floridae
ODC	-	Botrytis cinerea
ODC	-	Coccidioides immitis
ODC	-	Anopheles gambiae
ODC	-	Caenorhabditis briggsae
ODC	-	Culex pipiens
ODC	-	Ancylostoma ceylanicum
ODC	-	Takifugu rubripes
ODC	-	Petromyzon marinus
ODC	-	Parastagonospora nodorum
ODC	-	Uncinocarpus reesii
ODC	-	Hydra vulgaris
ODC	-	Tetraodon nigroviridis
ODC	-	Gasterosteus aculeatus
ODC	-	Dugesia japonica
ODC	-	Anolis carolinensis
ODC	-	Schmidtea mediterranea
ODC	-	Nasonia vitripennis

Cofactor

Cofactor	Comment	Organism
pyridoxal 5'-phosphate	dependent on	Gallus gallus
pyridoxal 5'-phosphate	dependent on	Drosophila melanogaster
pyridoxal 5'-phosphate	dependent on	Mus musculus
pyridoxal 5'-phosphate	dependent on	Homo sapiens
pyridoxal 5'-phosphate	dependent on	Rattus norvegicus
pyridoxal 5'-phosphate	dependent on	Bos taurus
pyridoxal 5'-phosphate	dependent on	Neurospora crassa
pyridoxal 5'-phosphate	dependent on	Trypanosoma brucei
pyridoxal 5'-phosphate	dependent on	Dictyostelium discoideum
pyridoxal 5'-phosphate	dependent on	Canis lupus familiaris
pyridoxal 5'-phosphate	dependent on	Xenopus laevis
pyridoxal 5'-phosphate	dependent on	Caenorhabditis elegans
pyridoxal 5'-phosphate	dependent on	Meyerozyma guilliermondii
pyridoxal 5'-phosphate	dependent on	Aedes aegypti
pyridoxal 5'-phosphate	dependent on	Aspergillus fischeri
pyridoxal 5'-phosphate	dependent on	Aspergillus terreus
pyridoxal 5'-phosphate	dependent on	Fusarium oxysporum
pyridoxal 5'-phosphate	dependent on	Fusarium verticillioides
pyridoxal 5'-phosphate	dependent on	Aspergillus clavatus
pyridoxal 5'-phosphate	dependent on	Aspergillus fumigatus
pyridoxal 5'-phosphate	dependent on	Ciona intestinalis
pyridoxal 5'-phosphate	dependent on	Branchiostoma floridae
pyridoxal 5'-phosphate	dependent on	Botrytis cinerea
pyridoxal 5'-phosphate	dependent on	Coccidioides immitis
pyridoxal 5'-phosphate	dependent on	Anopheles gambiae
pyridoxal 5'-phosphate	dependent on	Caenorhabditis briggsae
pyridoxal 5'-phosphate	dependent on	Culex pipiens
pyridoxal 5'-phosphate	dependent on	Ancylostoma ceylanicum
pyridoxal 5'-phosphate	dependent on	Takifugu rubripes
pyridoxal 5'-phosphate	dependent on	Petromyzon marinus
pyridoxal 5'-phosphate	dependent on	Parastagonospora nodorum
pyridoxal 5'-phosphate	dependent on	Uncinocarpus reesii
pyridoxal 5'-phosphate	dependent on	Hydra vulgaris
pyridoxal 5'-phosphate	dependent on	Tetraodon nigroviridis
pyridoxal 5'-phosphate	dependent on	Gasterosteus aculeatus
pyridoxal 5'-phosphate	dependent on	Dugesia japonica
pyridoxal 5'-phosphate	dependent on	Anolis carolinensis
pyridoxal 5'-phosphate	dependent on	Schmidtea mediterranea
pyridoxal 5'-phosphate	dependent on	Nasonia vitripennis