Activating Compound | Comment | Organism | Structure |
---|---|---|---|
progesterone | ODC activity gradually increases in the presence of progesterone | Xenopus laevis |
Cloned (Comment) | Organism |
---|---|
ODC expression analysis, overview | Xenopus laevis |
Protein Variants | Comment | Organism |
---|---|---|
additional information | inhibition of ODC translation by antisense morpholino oligos, xODC mo, abolishes ODC activity increase during oocyte maturation | Xenopus laevis |
General Stability | Organism |
---|---|
ODC has a very short half-life | Xenopus laevis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
alpha-difluoromethylornithine | a highly specific suicide inhibitor of ODC causing complete, irreversible inhibition | Xenopus laevis | |
antizyme | ODC antizyme, a polyamine-induced protein, binds ODC, serving to inhibit ODC activity and to promote proteasome-mediated ODC degradation | Xenopus laevis |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Xenopus laevis | 5737 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-ornithine | Xenopus laevis | ODC is the rate-limiting enzyme in the cellular biosynthetic pathway to polyamines putrescine, spermidine and spermine. During mitotic cell cycle, ODC exhibits two activity peaks, one at G1/S transition and the second during G2/M transition, anti-apoptotic role for ornithine decarboxylase during oocyte maturation, overview | putrescine + CO2 | - |
? | |
additional information | Xenopus laevis | ODC degradation is catalyzed by the 26S proteasome without prior polyubiquitination | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Xenopus laevis | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | during mitotic cell cycle, ODC exhibits two activity peaks, one at G1/S transition and the second during G2/M transition | Xenopus laevis | - |
oocyte | - |
Xenopus laevis | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-ornithine | - |
Xenopus laevis | putrescine + CO2 | - |
? | |
L-ornithine | ODC is the rate-limiting enzyme in the cellular biosynthetic pathway to polyamines putrescine, spermidine and spermine. During mitotic cell cycle, ODC exhibits two activity peaks, one at G1/S transition and the second during G2/M transition, anti-apoptotic role for ornithine decarboxylase during oocyte maturation, overview | Xenopus laevis | putrescine + CO2 | - |
? | |
additional information | ODC degradation is catalyzed by the 26S proteasome without prior polyubiquitination | Xenopus laevis | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ODC | - |
Xenopus laevis |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Xenopus laevis |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Xenopus laevis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Xenopus laevis |