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Literature summary for 4.1.1.17 extracted from

  • Zhou, Y.; Ma, C.; Karmouch, J.; Arabi Katbi, H.; Liu, X.J.
    An anti-apoptotic role for ornithine decarboxylase during oocyte maturation (2009), Mol. Cell. Biol., 29, 1786-1795.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
progesterone ODC activity gradually increases in the presence of progesterone Xenopus laevis

Cloned(Commentary)

Cloned (Comment) Organism
ODC expression analysis, overview Xenopus laevis

Protein Variants

Protein Variants Comment Organism
additional information inhibition of ODC translation by antisense morpholino oligos, xODC mo, abolishes ODC activity increase during oocyte maturation Xenopus laevis

General Stability

General Stability Organism
ODC has a very short half-life Xenopus laevis

Inhibitors

Inhibitors Comment Organism Structure
alpha-difluoromethylornithine a highly specific suicide inhibitor of ODC causing complete, irreversible inhibition Xenopus laevis
antizyme ODC antizyme, a polyamine-induced protein, binds ODC, serving to inhibit ODC activity and to promote proteasome-mediated ODC degradation Xenopus laevis

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Xenopus laevis 5737
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-ornithine Xenopus laevis ODC is the rate-limiting enzyme in the cellular biosynthetic pathway to polyamines putrescine, spermidine and spermine. During mitotic cell cycle, ODC exhibits two activity peaks, one at G1/S transition and the second during G2/M transition, anti-apoptotic role for ornithine decarboxylase during oocyte maturation, overview putrescine + CO2
-
?
additional information Xenopus laevis ODC degradation is catalyzed by the 26S proteasome without prior polyubiquitination ?
-
?

Organism

Organism UniProt Comment Textmining
Xenopus laevis
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information during mitotic cell cycle, ODC exhibits two activity peaks, one at G1/S transition and the second during G2/M transition Xenopus laevis
-
oocyte
-
Xenopus laevis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-ornithine
-
Xenopus laevis putrescine + CO2
-
?
L-ornithine ODC is the rate-limiting enzyme in the cellular biosynthetic pathway to polyamines putrescine, spermidine and spermine. During mitotic cell cycle, ODC exhibits two activity peaks, one at G1/S transition and the second during G2/M transition, anti-apoptotic role for ornithine decarboxylase during oocyte maturation, overview Xenopus laevis putrescine + CO2
-
?
additional information ODC degradation is catalyzed by the 26S proteasome without prior polyubiquitination Xenopus laevis ?
-
?

Synonyms

Synonyms Comment Organism
ODC
-
Xenopus laevis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Xenopus laevis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Xenopus laevis

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
Xenopus laevis