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Literature summary for 4.1.1.17 extracted from

  • Snapir, Z.; Keren-Paz, A.; Bercovich, Z.; Kahana, C.
    Antizyme-3 inhibits polyamine uptake and ornithine decarboxylase (ODC) activity, but does not stimulate ODC degradation (2008), Biochem. J., 419, 99-103.
    View publication on PubMed

General Stability

General Stability Organism
antizyme 3 stabilize the enzyme Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
antizyme antizymes are small polyamine-induced proteins that function as feedback regulators of cellular polyamine homeostasis. They bind to transient ODC monomeric subunits, resulting in inhibition of ODC activity and targeting ODC to ubiquitin-independent proteasomal degradation, unlike antizyme 1 and antizyme 2, which efficiently inhibit ODC activity and stimulate its proteasomal degradation, antizyme 3 poorly inhibits ODC activity and fails to promote ODC degradation. Furthermore, Az3 actually stabilizes ODC, probably by protecting it from the effect of Az1, overview. Interaction with antizyme stimulates ODC degradation due to a conformational change resulting in the exposure of it C-terminal proteasome recognition signal, overview. Az2 and Az3 are cloned by RT-PCR using RNA isolated from mouse liver and testis respectively, and expressed in HEK-293 cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-ornithine Homo sapiens ODC is the first rate-limiting enzyme in the polyamine biosynthesis pathway putrescine + CO2
-
?
additional information Homo sapiens ODC is degraded by the 26S proteasome after being ubiquinated, ODC degradation is greatly stimulated by its interaction with a polyamine-induced protein termed antizyme, interaction with antizyme stimulates ODC degradation due to a conformational change resulting in the exposure of it C-terminal proteasome recognition signal, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-ornithine
-
Homo sapiens putrescine + CO2
-
?
L-ornithine ODC is the first rate-limiting enzyme in the polyamine biosynthesis pathway Homo sapiens putrescine + CO2
-
?
additional information ODC is degraded by the 26S proteasome after being ubiquinated, ODC degradation is greatly stimulated by its interaction with a polyamine-induced protein termed antizyme, interaction with antizyme stimulates ODC degradation due to a conformational change resulting in the exposure of it C-terminal proteasome recognition signal, overview Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
ODC
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
Homo sapiens