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Literature summary for 4.1.1.17 extracted from
- Ornithine decarboxylase activity in tumor cell lines correlates with sensitivity to cell death induced by histone deacetylase inhibitors (2006), Mol. Cancer Ther., 5, 2777-2785.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | trichostatin A induces ODC activity and cell death in cancer cells | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| alpha-difluoromethylornithine | inhibition of ODC by alpha-difluoromethylornithine increases resistance to trichostatin A-induced cell death in HCT116 cells | Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-ornithine | Homo sapiens | the enzyme is involved in polyamine biosynthesis, polyamines participate in the cellular response to different structural classes of histone deacetylase inhibitors, overview | putrescine + CO2 | - |
? | |
| additional information | Homo sapiens | ODC activity in tumor cell lines correlates with sensitivity to cell death induced by histone deacetylase inhibitors, polyamine depletion increases resistance to trichostatin A-induced cell death, but the G1 arrest in cell cycle is not sufficient, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| A-431 cell | epithelial carcinoma cells | Homo sapiens | - |
| A-549 cell | lung carcinoma cells | Homo sapiens | - |
| fibroblast | neonatal foreskin fibroblasts | Homo sapiens | - |
| HCT-116 cell | colon carcinoma cells | Homo sapiens | - |
| HeLa cell | cervical carcinoma cells | Homo sapiens | - |
| additional information | ODC activity is elevated in tumor cells | Homo sapiens | - |
| NCI-H1299 cell | lung carcinoma cells | Homo sapiens | - |
| U2-OS cell | osteosarcoma cells | Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide cell viability assay | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-ornithine | - |
Homo sapiens | putrescine + CO2 | - |
? | |
| L-ornithine | the enzyme is involved in polyamine biosynthesis, polyamines participate in the cellular response to different structural classes of histone deacetylase inhibitors, overview | Homo sapiens | putrescine + CO2 | - |
? | |
| additional information | ODC activity in tumor cell lines correlates with sensitivity to cell death induced by histone deacetylase inhibitors, polyamine depletion increases resistance to trichostatin A-induced cell death, but the G1 arrest in cell cycle is not sufficient, overview | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ODC | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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