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Literature summary for 4.1.1.17 extracted from

  • Bauer, P.M.; Buga, G.M.; Fukuto, J.M.; Pegg, A.E.; Ignarro, L.J.
    Nitric oxide inhibits ornithine decarboxylase via S-nitrosylation of cysteine 360 in the active site of the enzyme (2001), J. Biol. Chem., 276, 34458-34464.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
C360A 2% of wild-type activity Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
1-diethyl-2-hydroxy-2-nitroso-hydrazine nitric oxide donor, inhibition via S-nitrosylation of Cys360 in the active site of ODC Rattus norvegicus
S-nitrosoglutathione inhibition likely via S-transnitrosation Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-ornithine Rattus norvegicus first step in polyamine biosynthesis putrescine + CO2
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinnt ODC Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-ornithine
-
Rattus norvegicus putrescine + CO2
-
?
L-ornithine first step in polyamine biosynthesis Rattus norvegicus putrescine + CO2
-
?

Synonyms

Synonyms Comment Organism
ODC
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
Rattus norvegicus