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Literature summary for 4.1.1.17 extracted from
- Comparison of biochemical and immunological properties between rat and Nicotiana glutinosa ornithine decarboxylase (2001), J. Biochem. Mol. Biol., 34, 408-414.
No PubMed abstract available
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| spermidine | 1 mM, 211% activation | Nicotiana glutinosa |  |
| spermine | 1 mM, 309% activation | Nicotiana glutinosa | |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 4-chloromercuribenzoate | 0.01 mM, complete inhibition | Nicotiana glutinosa | |
| 4-chloromercuribenzoate | 0.01 mM, 99% inhibition | Rattus norvegicus | |
| 5,5'-dithiobis(2-nitrobenzoic acid) | 0.01 mM, 99% inhibition | Nicotiana glutinosa | |
| 5,5'-dithiobis(2-nitrobenzoic acid) | 0.01 mM, 98% inhibition | Rattus norvegicus | |
| agmatine | 1 mM, 77% inhibition | Nicotiana glutinosa | |
| cadaverine | 1 mM, 46% inhibition | Nicotiana glutinosa | |
| ethyl[dimethylaminopropyl]carbodiimide | 1.0 mM, 54% inhibition | Nicotiana glutinosa | |
| ethyl[dimethylaminopropyl]carbodiimide | 1.0 mM, 52% inhibition | Rattus norvegicus | |
| MTA | 1 mM, 70% inhibition | Rattus norvegicus | |
| N-ethylmaleimide | 0.01 mM, complete inhibition | Nicotiana glutinosa | |
| N-ethylmaleimide | 0.01 mM, 99% inhibition | Rattus norvegicus | |
| Phenylglyoxal | 1.0 mM, 36% inhibition | Nicotiana glutinosa | |
| Phenylglyoxal | 1.0 mM, 71% inhibition | Rattus norvegicus | |
| putrescine | 1 mM, 70% inhibition | Nicotiana glutinosa | |
| putrescine | 1 mM, 63% inhibition | Rattus norvegicus | |
| Salicylaldehyde | 1.0 mM, 98% inhibition | Nicotiana glutinosa | |
| Salicylaldehyde | 1.0 mM, 82% inhibition | Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 46000 | - |
2 * 46000, SDS-PAGE | Nicotiana glutinosa |
| 53000 | - |
2 * 53000, SDS-PAGE | Rattus norvegicus |
| 92000 | - |
native PAGE | Nicotiana glutinosa |
| 106000 | - |
native PAGE | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-ornithine | Nicotiana glutinosa | - |
putrescine + CO2 | - |
? | |
| L-ornithine | Rattus norvegicus | - |
putrescine + CO2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Nicotiana glutinosa | Q9FPK5 | - |
- |
| Rattus norvegicus | P09057 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant ODC | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-ornithine | - |
Nicotiana glutinosa | putrescine + CO2 | - |
? | |
| L-ornithine | - |
Rattus norvegicus | putrescine + CO2 | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 53000, SDS-PAGE | Rattus norvegicus |
| dimer | 2 * 46000, SDS-PAGE | Nicotiana glutinosa |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ODC | - |
Nicotiana glutinosa |
| ODC | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | - |
Nicotiana glutinosa | |
| pyridoxal 5'-phosphate | - |
Rattus norvegicus | |
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