Literature summary for 4.1.1.17 extracted from

Krause, T.; Luersen, K.; Wrenger, C.; Gilberger, T.W.; Muller, S.; Walter, R.D.
The ornithine decarboxylase domain of the bifunctional ornithine decarboxylase/S-adenosylmethionine decarboxylase of Plasmodium falciparum: recombinant expression and catalytic properties of two different constructs (2000), Biochem. J., 352, 287-292.

Search for more literature for 4.1.1.17

Cloned(Commentary)

Cloned (Comment)	Organism
expression of ODC domain, i.e. rPfODC, and ODC domain in conjunction with the preceeding part of the hinge region of the bifunctional ODC/AdoMetDC, i.e.rPfHinge-ODC, in Escherichia coli	Plasmodium falciparum

Inhibitors

Inhibitors	Comment	Organism	Structure
alpha-difluoroornithine	-	Plasmodium falciparum
CGP52622A	3-amino-oxy-1-propanamine analog, 0.00006 mM, 50% inhibition of recombinant Pf-Hinge-ODC	Plasmodium falciparum
CGP54619A	3-amino-oxy-1-propanamine analog, 0.000025 mM, 50% inhibition of recombinant Pf-Hinge-ODC	Plasmodium falciparum
putrescine	-	Plasmodium falciparum
spermidine	1 mM, 61% inhibition of recombinant-Hinge-ODC and 63% inhibition of recombinant PfODC	Plasmodium falciparum

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.047	-	L-ornithine	recombinant Pf-Hinge-ODC	Plasmodium falciparum
0.16	-	L-ornithine	recombinant PfODC domain	Plasmodium falciparum

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-ornithine	Plasmodium falciparum	-	putrescine + CO2	-	?

Organism

Organism	UniProt	Comment	Textmining
Plasmodium falciparum	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
recombinant PfODC and Pf-Hinge-ODC	Plasmodium falciparum

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
0.0043	-	recombinant pF-Hinge-ODC	Plasmodium falciparum

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-ornithine	-	Plasmodium falciparum	putrescine + CO2	-	?

Synonyms

Synonyms	Comment	Organism
ODC	-	Plasmodium falciparum

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
0.003	-	L-ornithine	recombinant PfODC domain	Plasmodium falciparum
0.006	-	L-ornithine	recombinant Pf-Hinge-ODC	Plasmodium falciparum

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7	8	recombinant PfODC domain	Plasmodium falciparum
7.5	8.5	recombinant Pf-Hinge-ODC	Plasmodium falciparum

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.000008	-	CGP54619A	-	Plasmodium falciparum
0.00002	-	CGP52622A	-	Plasmodium falciparum
0.05	-	putrescine	recombinant Pf-Hinge-ODC	Plasmodium falciparum
0.09	-	alpha-difluoroornithine	recombinant Pf-Hinge-ODC	Plasmodium falciparum
0.16	-	putrescine	recombinant PfODC domain	Plasmodium falciparum

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Release 2023.1 (January 2023)