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Literature summary for 4.1.1.15 extracted from

  • Begley, M.; Cotter, P.D.; Hill, C.; Ross, R.P.
    Glutamate decarboxylase-mediated nisin resistance in Listeria monocytogenes (2010), Appl. Environ. Microbiol., 76, 6541-6546.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.1.1.15

Application

Application Comment Organism
food industry the specific inhibition of GAD activity or a reduction in the levels of free glutamate may prevent the growth of otherwise resistant GAD+ bacteria in foods where low pH and/or nisin is used as a preservative Lactococcus lactis subsp. lactis
food industry the specific inhibition of GAD activity or a reduction in the levels of free glutamate may prevent the growth of otherwise resistant GAD+ bacteria in foods where low pH and/or nisin is used as a preservative Listeria monocytogenes

Organism

Organism UniProt Comment Textmining
Lactococcus lactis subsp. lactis
-
-
-
Lactococcus lactis subsp. lactis IL1403
-
-
-
Listeria monocytogenes
-
-
-
Listeria monocytogenes LO28
-
-
-
no activity in Lactococcus lactis subsp. cremoris
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-glutamate
-
 Lactococcus lactis subsp. lactis 4-aminobutanoate + CO2
-
 ?
L-glutamate
-
 Listeria monocytogenes 4-aminobutanoate + CO2
-
 ?
L-glutamate
-
 Lactococcus lactis subsp. lactis IL1403 4-aminobutanoate + CO2
-
 ?
L-glutamate
-
 Listeria monocytogenes LO28 4-aminobutanoate + CO2
-
 ?

Synonyms

Synonyms Comment Organism
GAD
-
 Lactococcus lactis subsp. lactis
GAD
-
 Listeria monocytogenes

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Lactococcus lactis subsp. lactis
pyridoxal 5'-phosphate
-
 Listeria monocytogenes

General Information

General Information Comment Organism
malfunction survival of the gadB mutant after 60 min in the presence of 0.045 mg/ml nisin powder is approximately 5fold less than that of the parental strain Lactococcus lactis subsp. lactis
malfunction the DELTAgadD1 mutant is impaired in its ability to tolerate exposure to both sublethal and lethal levels of the lantibiotic nisin Listeria monocytogenes
physiological function possession of the gadD1 gene correlates with a higher degree of tolerance to nisin Lactococcus lactis subsp. lactis
physiological function possession of the gadD1 gene correlates with a higher degree of tolerance to nisin Listeria monocytogenes