Literature summary for 4.1.1.15 extracted from

Arunchaipong, K.; Sattayasai, N.; Sattayasai, J.; Svasti, J.; Rimlumduan, T.
A biotin-coupled bifunctional enzyme exhibiting both glutamine synthetase activity and glutamate decarboxylase activity (2009), Curr. Eye Res., 34, 809-818.

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Inhibitors

Inhibitors	Comment	Organism	Structure
Avidin	-	Gallus gallus
additional information	the glutamate decarboxylase activity of p42 is not inhibited by high concentrations of Mn2+	Gallus gallus

Metals/Ions

Metals/Ions	Comment	Organism	Structure
additional information	Mn2+ shows no effect on glutamate decarboxylase activity	Gallus gallus

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
42000	-	SDS-PAGE	Gallus gallus

Organism

Organism	UniProt	Comment	Textmining
Gallus gallus	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
centricon-100 gel filtration	Gallus gallus

Source Tissue

Source Tissue	Comment	Organism	Textmining
retina	-	Gallus gallus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-glutamate	the reaction does not occur, when L-glutamate concentration is more than 4fold that of L-glutamine	Gallus gallus	4-aminobutanoate + CO2	-	?

Subunits

Subunits	Comment	Organism
homooctamer	native PAGE	Gallus gallus
homotetramer	native PAGE	Gallus gallus

Synonyms

Synonyms	Comment	Organism
42 kDa biotin-coupled protein	exhibits both glutamine synthetase activity and glutamate decarboxylase activity	Gallus gallus
p42	exhibits both glutamine synthetase activity and glutamate decarboxylase activity	Gallus gallus

pI Value

Organism	Comment	pI Value Maximum	pI Value
Gallus gallus	at the position of 42 kDa four protein spots with the pI-values 6.8, 6.9, 7.1, and 7.3 are found, isoelectric focusing	-	6.8
Gallus gallus	at the position of 42 kDa four protein spots with the pI-values 6.8, 6.9, 7.1, and 7.3 are found, isoelectric focusing	-	6.9
Gallus gallus	at the position of 42 kDa four protein spots with the pI-values 6.8, 6.9, 7.1, and 7.3 are found, isoelectric focusing	-	7.1
Gallus gallus	at the position of 42 kDa four protein spots with the pI-values 6.8, 6.9, 7.1, and 7.3 are found, isoelectric focusing	-	7.3

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Release 2023.1 (January 2023)