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Literature summary for 4.1.1.15 extracted from

  • El-Faramawy, Y.A.; El-Banouby, M.H.; Sergeev, P.; Mortagy, A.K.; Amer, M.S.; Abdel-Tawab, A.M.
    Changes in glutamate decarboxylase enzyme activity and tau-protein phosphorylation in the hippocampus of old rats exposed to chronic mild stress: Reversal with the neuronal nitric oxide synthase inhibitor 7-nitroindazole (2009), Pharmacol. Biochem. Behav., 91, 339-344.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
additional information chronic mild stress leads to 60% reduced enzyme activity in old rats, which is reversible by neuronal nitric oxide synthase inhibitor 7-nitroindazole, overview Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-glutamate Rattus norvegicus the enzyme activity is higher in hippocampus of old rats compared to young rats 4-aminobutanoate + CO2
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 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 male Wistar rats
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Source Tissue

Source Tissue Comment Organism Textmining
hippocampus the enzyme activity is higher in hippocampus of old rats compared to young rats Rattus norvegicus
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 enzyme activity in hippocampi of young and old rats Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-glutamate
-
 Rattus norvegicus 4-aminobutanoate + CO2
-
 ?
L-glutamate the enzyme activity is higher in hippocampus of old rats compared to young rats Rattus norvegicus 4-aminobutanoate + CO2
-
 ?

Synonyms

Synonyms Comment Organism
GAD
-
 Rattus norvegicus