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Literature summary for 4.1.1.15 extracted from

  • Yamamoto, N.; Soghomonian, J.
    Time-course of SKF-81297-induced increase in glutamic acid decarboxylase 65 and 67 mRNA levels in striatonigral neurons and decrease in GABAA receptor alpha 1 subunit mRNA levels in the substantia nigra, pars reticulata, in adult rats with a unilateral 6-hydroxydopamine lesion (2008), Neuroscience, 154, 1088-1099.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information increased GAD or vGAT mRNA levels after acute SKF-81297 occurr in striatonigral neurons. Subchronic SKF-81297 induces significant increases in striatal GAD67, GAD65, preprodynorphin, and vGAT mRNA levels and decreases in nigral alpha1 mRNA levels. In the striatum contralateral to the 6-OHDA lesion, subchronic but not acute SKF-81297 induced a significant increase in GAD65 mRNA levels Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
genes GAd65 and GAD67, expression analysis in brain tissues Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
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Rattus norvegicus 5829
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus chronic systemic administration of an agonist of dopamine D1/D5-preferring receptors increases GAD mRNA levels in striatonigral neurons in intact and dopamine-depleted rats. striatal GAD67 mRNA levels were negatively correlated with nigral alpha1 mRNA levels in the dopamine-depleted but not dopamine-intact side. down-regulation of nigral GABAA receptors is linked to the increase in striatal GAD67 mRNA levels in the dopamine-depleted striatum. Different signaling pathways are involved in the modulation by dopamine D1/D5 receptors of GAD65 and GAD67 mRNA levels in striatonigral neurons, overview ?
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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male sprague-dawley rats
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Source Tissue

Source Tissue Comment Organism Textmining
brain
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Rattus norvegicus
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corpus striatum
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Rattus norvegicus
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additional information GAD65, GAD67, PPD and vGAT mRNA levels in the striatum and GABAA receptor alpha1 subunit mRNA levels in the substantia nigra, pars reticulata, and striatum in rats with single or subchroninc application of unilateral 6-hydroxydopamine lesion, overview Rattus norvegicus
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neuron
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Rattus norvegicus
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pars reticulata
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Rattus norvegicus
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substantia nigra
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Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information chronic systemic administration of an agonist of dopamine D1/D5-preferring receptors increases GAD mRNA levels in striatonigral neurons in intact and dopamine-depleted rats. striatal GAD67 mRNA levels were negatively correlated with nigral alpha1 mRNA levels in the dopamine-depleted but not dopamine-intact side. down-regulation of nigral GABAA receptors is linked to the increase in striatal GAD67 mRNA levels in the dopamine-depleted striatum. Different signaling pathways are involved in the modulation by dopamine D1/D5 receptors of GAD65 and GAD67 mRNA levels in striatonigral neurons, overview Rattus norvegicus ?
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Synonyms

Synonyms Comment Organism
GAD
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Rattus norvegicus
GAD65
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Rattus norvegicus
GAD67
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Rattus norvegicus
Glutamic acid decarboxylase
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Rattus norvegicus