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Literature summary for 4.1.1.15 extracted from
- Reversibility of cerebellar GABAergic synapse impairment induced by anti-glutamic acid decarboxylase autoantibodies (2008), J. Neurol. Sci., 271, 186-190.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-glutamate | Homo sapiens | - |
4-aminobutanoate + CO2 | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Homo sapiens | - |
| cerebellum | cerebrospinal fluid elicits physiopathological effects on cerebellar GABA synapses in vitro, cerebrospinal fluid IgG-induced depressive effects are abolished by absorption of GAD-antibodies using recombinant GAD. Furthermore, forskolin, an activator of cAMP, recovers the cerebrospinal fluid IgG-induced reduction of GABA release | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-glutamate | - |
Homo sapiens | 4-aminobutanoate + CO2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| GAD | - |
Homo sapiens |
| Glutamic acid decarboxylase | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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