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Literature summary for 4.1.1.15 extracted from

  • Inoue, Y.; Ishii, K.; Miyazaki, M.; Ueno, H.
    Purification of L-glutamate decarboxylase from monkey brain (2008), Biosci. Biotechnol. Biochem., 72, 2269-2276.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
L-Gln activates 18% at 1 mM Macaca fuscata

Inhibitors

Inhibitors Comment Organism Structure
Glutarate inhibits 42% at 1 mM Macaca fuscata
L-Asn inhibits 4% at 1 mM Macaca fuscata
L-Asp inhibits 20% at 1 mM Macaca fuscata
L-Glu inhibits 25% at 1 mM Macaca fuscata

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
66000
-
gel filtration Macaca fuscata

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-glutamate Macaca fuscata
-
4-aminobutanoate + CO2
-
?

Organism

Organism UniProt Comment Textmining
Macaca fuscata
-
male monkeys
-

Purification (Commentary)

Purification (Comment) Organism
native enzyme 550fold from brain by ammonium sulfate fractionation, hydrophobic interaction chromatography inpresence of benzamidine, ultrafiltration, anion exchange chromatography, and gel filtration Macaca fuscata

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Macaca fuscata
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0011
-
purified native enzyme Macaca fuscata

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-glutamate
-
Macaca fuscata 4-aminobutanoate + CO2
-
?

Synonyms

Synonyms Comment Organism
GAD
-
Macaca fuscata
GAD65
-
Macaca fuscata
L-Glutamate decarboxylase
-
Macaca fuscata

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37 50
-
Macaca fuscata

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7 8
-
Macaca fuscata

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
Macaca fuscata