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Literature summary for 4.1.1.15 extracted from

  • Matthews, C.C.; Zielke, H.R.; Fishman, P.S.; Remington, M.P.; Bowen, T.G.
    Glutamate decarboxylase protects neurons against excitotoxic injury (2007), J. Neurosci. Res., 85, 855-859.
    View publication on PubMed

Application

Application Comment Organism
medicine incubation of rat hippocampal slices with the potassium channel antagonis tetraethyl ammonium results in widespread excitotoxic death of pyramidal and granule cell neurons. Treatment with bacterial enzyme significantly reduces excitotoxicity induced by tetraethyl ammonium without showing neurotoxicity. Targeting of enzyme to the interior of synaptic vesicles may enhance its potency as a neuroprotectant Escherichia coli

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
52000
-
x * 52500, SDS-PAGE, x * 52000, calculated Escherichia coli
52500
-
x * 52500, SDS-PAGE, x * 52000, calculated Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
71 86
-
Escherichia coli

Storage Stability

Storage Stability Organism
-20°C, stable for several months without loss of activity Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-glutamate
-
Escherichia coli 4-aminobutanoate + CO2
-
?

Subunits

Subunits Comment Organism
? x * 52500, SDS-PAGE, x * 52000, calculated Escherichia coli