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Literature summary for 4.1.1.15 extracted from

  • Wu, H.; Jin, Y.; Buddhala, C.; Osterhaus, G.; Cohen, E.; Jin, H.; Wei, J.; Davis, K.; Obata, K.; Wu, J.Y.
    Role of glutamate decarboxylase (GAD) isoform, GAD65, in GABA synthesis and transport into synaptic vesicles - Evidence from GAD65-knockout mice studies (2007), Brain Res., 1154, 80-83.
    View publication on PubMed
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Protein Variants

Protein Variants Comment Organism
additional information isoform GAD65 knock-out mice show upregulated level of vesicular gamma-aminobutanoate transporter, and no change in the synaptic vesicles-associated isoform GAD67. In mutant mice, synaptic vesicles transport cytosolic gamma-aminobutanoate much more efficiently than wild-type Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus isoform GAD65 plays a major role in gamma-aminobutanoate transmission in normal physiological condition. Isoform GAD67 can serve this role under some pathological conditions ?
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Organism

Organism UniProt Comment Textmining
Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information isoform GAD65 plays a major role in gamma-aminobutanoate transmission in normal physiological condition. Isoform GAD67 can serve this role under some pathological conditions Mus musculus ?
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