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Literature summary for 4.1.1.15 extracted from

  • Davis, K.; Foos, T.; Wu, J.Y.; Schloss, J.V.
    Oxygen-induced seizures and inhibition of human glutamate decarboxylase and porcine cysteine sulfinic acid decarboxylase by oxygen and nitric oxide (2001), J. Biomed. Sci., 8, 359-364.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
NO
-
 Homo sapiens
O2
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Reaction

Reaction Comment Organism Reaction ID
L-glutamate = 4-aminobutanoate + CO2 reaction proceeds via radical mechanism Homo sapiens
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Glu
-
 Homo sapiens 4-Aminobutanoate + CO2
-
 ?

Synonyms

Synonyms Comment Organism
GAD65
-
 Homo sapiens
GAD67
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.29
-
 O2 pH 7.3, 25°C, GAD67, recombinant enzyme expressed in Escherichia coli Homo sapiens
0.46
-
 O2 pH 7.3, 25°C, GAD56, recombinant enzyme expressed in Escherichia coli Homo sapiens
0.5
-
 NO pH 7.3, 25°C, GAD65, recombinant enzyme expressed in Escherichia coli Homo sapiens
0.5
-
 NO pH 7.3, 25°C, GAD67, recombinant enzyme expressed in Escherichia coli Homo sapiens