Literature summary for 4.1.1.112 extracted from

Pircher, H.; von Grafenstein, S.; Diener, T.; Metzger, C.; Albertini, E.; Taferner, A.; Unterluggauer, H.; Kramer, C.; Liedl, K.R.; Jansen-Duerr, P.
Identification of FAH domain-containing protein 1 (FAHD1) as oxaloacetate decarboxylase (2015), J. Biol. Chem., 290, 6755-6762 .

Search for more literature for 4.1.1.112

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Mus musculus	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
D102A/R106A	the mutant shows about 3% of wild type activity	Homo sapiens
E33A	the mutant shows about 40% of wild type activity	Homo sapiens
H30A	the mutant shows about 20% of wild type activity	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
oxalate	potent competitive inhibition	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.032	-	oxaloacetate	at pH 7.4 and 25°C	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
fumarylpyruvate + H2O	Homo sapiens	-	fumarate + pyruvate + H+	-	?
oxaloacetate + H+	Homo sapiens	-	pyruvate + CO2	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q6P587	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
fumarylpyruvate + H2O	-	Homo sapiens	fumarate + pyruvate + H+	-	?
oxaloacetate + H+	-	Homo sapiens	pyruvate + CO2	-	?

Subunits

Subunits	Comment	Organism
homodimer	2 * 29000, SDS-PAGE	Homo sapiens

Synonyms

Synonyms	Comment	Organism
FAH domain-containing protein 1	-	Homo sapiens
FAHD1	-	Homo sapiens
fumarylacetoacetate hydrolase domain-containing protein 1	-	Homo sapiens
ODx	-	Homo sapiens

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.001	-	oxalate	at pH 7.4 and 25°C	Homo sapiens

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Release 2023.1 (January 2023)