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Literature summary for 4.1.1.112 extracted from

  • Dharmarajan, L.; Case, C.L.; Dunten, P.; Mukhopadhyay, B.
    Tyr235 of human cytosolic phosphoenolpyruvate carboxykinase influences catalysis through an anion-quadrupole interaction with phosphoenolpyruvate carboxylate (2008), FEBS J., 275, 5810-5819.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Homo sapiens

Protein Variants

Protein Variants Comment Organism
Y235A site-directed mutagenesis Homo sapiens
Y235F site-directed mutagenesis Homo sapiens
Y235S site-directed mutagenesis Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0003
-
oxaloacetate wild-type, Vmax = 4 micromol/min/mg Homo sapiens
0.0003
-
oxaloacetate Y235A mutant, Vmax = 0.2 micromol/min/mg. In the presence of GDP Homo sapiens
0.0003
-
oxaloacetate Y235F mutant, Vmax = 2 micromol/min/mg Homo sapiens
0.0003
-
oxaloacetate Y235S mutant, Vmax = 0.1 micromol/min/mg. In the presence of GDP Homo sapiens
0.0004
-
oxaloacetate wild-type, Vmax = 3 micromol/min/mg. In the presence of GDP Homo sapiens
0.0004
-
oxaloacetate Y235F mutant, Vmax = 3 micromol/min/mg. In the presence of GDP Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Oxaloacetate
-
Homo sapiens Pyruvate + CO2
-
?

Synonyms

Synonyms Comment Organism
OAD
-
Homo sapiens
oxaloacetate decarboxylase
-
Homo sapiens