Cloned (Comment) | Organism |
---|---|
gene panD, functional recombinant expression in enzyme-deficient Zymomonas mobilis strain ZM4, the heterologous expression of the Escherichia coli enzyme eliminates the need for exogenous pantothenate by the auxotrophic strain, that is incapable of making both beta-alanine and pantoate. beta-Alanine can substitute for pantothenate (pan) to support strain ZM4 growth | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-aspartate | Escherichia coli | - |
beta-alanine + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | P0A790 | - |
- |
no activity in Zymomonas mobilis | - |
Zymomonas mobilis ZM4 is auxotrophic for beta-alanine but not for pantoate. Strain ZM4 shows pantothenate auxotrophy due to the absence of the single gene, panD, encoding aspartate 1-decarboxylase. Heterologous expression of Escherichia coli PanD in Zymomonas mobilis or supplementation of the growth medium with the product of PanD activity, beta-alanine, eliminates the need for exogenous pantothenate | - |
no activity in Zymomonas mobilis ZM4 / ATCC 31821 / CP4 | - |
Zymomonas mobilis ZM4 is auxotrophic for beta-alanine but not for pantoate. Strain ZM4 shows pantothenate auxotrophy due to the absence of the single gene, panD, encoding aspartate 1-decarboxylase. Heterologous expression of Escherichia coli PanD in Zymomonas mobilis or supplementation of the growth medium with the product of PanD activity, beta-alanine, eliminates the need for exogenous pantothenate | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-aspartate | - |
Escherichia coli | beta-alanine + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PanD | - |
Escherichia coli |