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Literature summary for 4.1.1.11 extracted from

  • Sharma, R.; Florea, M.; Nau, W.M.; Swaminathan, K.
    Validation of drug-like inhibitors against Mycobacterium tuberculosis L-aspartate alpha-decarboxylase using nuclear magnetic resonance (1H NMR) (2012), PLoS ONE, 7, e45947.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.1.1.11

Cloned(Commentary)

Cloned (Comment) Organism
expression of His6tagged enzyme in Escherichia coli Mycobacterium tuberculosis

Inhibitors

Inhibitors Comment Organism Structure
(2S,3R,4S,5S)-2,3,4,6-tetrahydroxy-5-mercaptohexanal ZINC03871163 Mycobacterium tuberculosis
2,4-dihydroxypyrimidine-5-carboxylate ZINC00901606, moderate inhibition Mycobacterium tuberculosis
D-tagatose ZINC03830878, weak inhibition Mycobacterium tuberculosis
D-Tartrate ZINC00895296, strong inhibition Mycobacterium tuberculosis
DL-threo-beta-hydroxyaspartate strong inhibition Mycobacterium tuberculosis
L-cysteic acid strong inhibition Mycobacterium tuberculosis
L-glutamate strong inhibition Mycobacterium tuberculosis
L-serine weak inhibition Mycobacterium tuberculosis
L-Tartrate ZINC00895301, strong inhibition Mycobacterium tuberculosis
additional information no inhibition by D-serine, (4S)-1,3-thiazolidin-3-ium-4-carboxylate, alpha-D-arabinopyranose, and 1,2-dihydropyrazolo[3,4-d]pyrimidin-4-one Mycobacterium tuberculosis
oxaloacetate very strong inhibition Mycobacterium tuberculosis
succinate moderate inhibition Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-aspartate Mycobacterium tuberculosis
-
 beta-alanine + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
 gene panD
-

Purification (Commentary)

Purification (Comment) Organism
recombinant His6-tagged enzyme from Escherichia coli by nickel affinity chromatography, gel filtration, and dialysis Mycobacterium tuberculosis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-aspartate
-
 Mycobacterium tuberculosis beta-alanine + CO2
-
 ?

Synonyms

Synonyms Comment Organism
L-Aspartate alpha-decarboxylase
-
 Mycobacterium tuberculosis
MtbADC
-
 Mycobacterium tuberculosis