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Literature summary for 4.1.1.105 extracted from

  • De Masi, L.; Castaldo, D.; Pignone, D.; Servillo, L.; Facchiano, A.
    Experimental evidence and in silico identification of tryptophan decarboxylase in Citrus genus (2017), Molecules, 22, pii: E272 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
gene tdc, DNA and amino acid sequence determination and analysis, TDC is a homodimer and its polypeptide chain is encoded by a single copy gene without introns, sequence comparisons and phylogenetic tree Citrus sinensis
gene tdc, DNA and amino acid sequence determination and analysis, TDC is a homodimer and its polypeptide chain is encoded by a single copy gene without introns, sequence comparisons and phylogenetic tree Citrus clementina
gene tdc, TDC is a homodimer and its polypeptide chain is encoded by a single copy gene without introns, sequence comparisons Citrus limon

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tryptophan Citrus sinensis
-
tryptamine + CO2
-
?
L-tryptophan Citrus limon
-
tryptamine + CO2
-
?
L-tryptophan Citrus clementina
-
tryptamine + CO2
-
?

Organism

Organism UniProt Comment Textmining
Citrus clementina
-
-
-
Citrus limon
-
-
-
Citrus sinensis
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
leaf
-
Citrus sinensis
-
leaf
-
Citrus limon
-
leaf
-
Citrus clementina
-
seedling
-
Citrus sinensis
-
seedling
-
Citrus limon
-
seedling
-
Citrus clementina
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan
-
Citrus sinensis tryptamine + CO2
-
?
L-tryptophan
-
Citrus limon tryptamine + CO2
-
?
L-tryptophan
-
Citrus clementina tryptamine + CO2
-
?
additional information enzyme TDC has substrate specificity for Trp, but not for phenolic L-amino acids (Phe and Tyr) and their derivatives, substrate binding site sequence determination Citrus sinensis ?
-
?
additional information enzyme TDC has substrate specificity for Trp, but not for phenolic L-amino acids (Phe and Tyr) and their derivatives, substrate binding site sequence determination Citrus limon ?
-
?
additional information enzyme TDC has substrate specificity for Trp, but not for phenolic L-amino acids (Phe and Tyr) and their derivatives, substrate binding site sequence determination Citrus clementina ?
-
?

Synonyms

Synonyms Comment Organism
TDC
-
Citrus sinensis
TDC
-
Citrus limon
TDC
-
Citrus clementina
Tryptophan decarboxylase
-
Citrus sinensis
Tryptophan decarboxylase
-
Citrus limon
Tryptophan decarboxylase
-
Citrus clementina

Temperature Optimum [┬░C]

Temperature Optimum [┬░C] Temperature Optimum Maximum [┬░C] Comment Organism
37
-
assay at Citrus sinensis
37
-
assay at Citrus limon
37
-
assay at Citrus clementina

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5 7.5 assay at Citrus sinensis
5 7.5 assay at Citrus limon
5 7.5 assay at Citrus clementina

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
Citrus sinensis
pyridoxal 5'-phosphate
-
Citrus limon
pyridoxal 5'-phosphate
-
Citrus clementina

General Information

General Information Comment Organism
metabolism plant tryptophan decarboxylase (TDC) converts tryptophan into tryptamine, precursor of indolealkylamine alkaloids. Successive methylation pathway of the tryptamine to N,N,N-trimethyltryptamine produced from the tryptophan decarboxylation, overview Citrus sinensis
metabolism plant tryptophan decarboxylase (TDC) converts tryptophan into tryptamine, precursor of indolealkylamine alkaloids. Successive methylation pathway of the tryptamine to N,N,N-trimethyltryptamine produced from the tryptophan decarboxylation, overview Citrus limon
metabolism plant tryptophan decarboxylase (TDC) converts tryptophan into tryptamine, precursor of indolealkylamine alkaloids. Successive methylation pathway of the tryptamine to N,N,N-trimethyltryptamine produced from the tryptophan decarboxylation, overview Citrus clementina
physiological function plant tryptophan decarboxylase (TDC) converts tryptophan into tryptamine, precursor of indolealkylamine alkaloids Citrus sinensis
physiological function plant tryptophan decarboxylase (TDC) converts tryptophan into tryptamine, precursor of indolealkylamine alkaloids Citrus limon
physiological function plant tryptophan decarboxylase (TDC) converts tryptophan into tryptamine, precursor of indolealkylamine alkaloids Citrus clementina