Literature summary for 4.1.1.1 extracted from

Lee, W.; Seo, S.; Bae, Y.; Nan, H.; Jin, Y.; Seo, J.
Isobutanol production in engineered Saccharomyces cerevisiae by overexpression of 2-ketoisovalerate decarboxylase and valine biosynthetic enzymes (2012), Bioprocess Biosyst. Eng., 35, 1467-1475.

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Application

Application	Comment	Organism
synthesis	construction of isobutanol production systems by overexpression of effective 2-oxoacid decarboxylase KivD and combinatorial overexpression of valine biosynthetic enzymes in Saccharomyces cerevisiae D452-2. Isobutanol production by the engineered strain is assessed in micro-aerobic batch fermentations using glucose as a sole carbon source, leading to priduction of 93 mg/l isobutanol, which corresponds to a fourfold improvement as compared with the control strain. Isobutanol production is further enhanced to 151 mg/l by additional overexpression of acetolactate synthase Ilv2p, acetohydroxyacid reductoisomerase Ilv5p, and dihydroxyacid dehydratase Ilv3p in the cytosol	Lactococcus lactis subsp. lactis

Organism

Organism	UniProt	Comment	Textmining
Lactococcus lactis subsp. lactis	-	-	-
Lactococcus lactis subsp. lactis KACC13877	-	-	-

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Release 2023.1 (January 2023)