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Literature summary for 4.1.1.1 extracted from

  • Lie, M.A.; Celik, L.; Jorgensen, K.A.; Schiott, B.
    Cofactor activation and substrate binding in pyruvate decarboxylase. Insights into the reaction mechanism from molecular dynamics simulations (2005), Biochemistry, 44, 14792-14806.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Zymomonas mobilis P06672
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Reaction

Reaction Comment Organism Reaction ID
a 2-oxo carboxylate = an aldehyde + CO2 in absence of substrate, equilibrium is shifted to 4'-aminopyridine thiamine diphosphate. Carbonyl group of substrate forms a hydrogen bond to Tyr290, geometry of substrate is well-suited for a nucleophilic attack by ylide-thiamine diphosphate Zymomonas mobilis