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Literature summary for 3.8.1.6 extracted from

  • Gilmartin, N.; Ryan, D.; Dowling, D.N.
    Analysis of the C-terminal domain of Burkholderia sp. strain LB400 BphK reveals a conserved motif that affects catalytic activity (2005), FEMS Microbiol. Lett., 249, 23-30.
    View publication on PubMed
Search for more literature for 3.8.1.6

Protein Variants

Protein Variants Comment Organism
A154R 84% of wild-type activity with 1-chloro-2,4-dinitrobenzene, 57% of wild-type activity with 4-chlorobenzoate Burkholderia sp.
A154S 84% of wild-type activity with 1-chloro-2,4-dinitrobenzene, 47% of wild-type activity with 4-chlorobenzoate Burkholderia sp.
D155Y no decrease in glutathione S-transferase actvitiy, affected in thermostability, 96% of wild-type activity with 1-chloro-2,4-dinitrobenzene, 95% of wild-type activity with 4-chlorobenzoate Burkholderia sp.
L158P 56% of wild-type activity with 1-chloro-2,4-dinitrobenzene, 50% of wild-type activity with 4-chlorobenzoate Burkholderia sp.
S152G 4% of wild-type activity with 1-chloro-2,4-dinitrobenzene, 3% of wild-type activity with 4-chlorobenzoate Burkholderia sp.
S152I 53% of wild-type activity with 1-chloro-2,4-dinitrobenzene, 156% of wild-type activity with 4-chlorobenzoate Burkholderia sp.
V153I 56% of wild-type activity with 1-chloro-2,4-dinitrobenzene, 52% of wild-type activity with 4-chlorobenzoate Burkholderia sp.
V153R 4% of wild-type activity with 1-chloro-2,4-dinitrobenzene, 39% of wild-type activity with 4-chlorobenzoate Burkholderia sp.
Y157W 49% of wild-type activity with 1-chloro-2,4-dinitrobenzene, 59% of wild-type activity with 4-chlorobenzoate Burkholderia sp.

Organism

Organism UniProt Comment Textmining
Burkholderia sp. Q59721 additional activity of glutathione-s-transferase
-
Burkholderia sp. LB400 Q59721 additional activity of glutathione-s-transferase
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-chloro-2,4-dinitrobenzene + H2O
-
 Burkholderia sp. 2,4-dinitrophenol + chloride
-
 ?
1-chloro-2,4-dinitrobenzene + H2O
-
 Burkholderia sp. LB400 2,4-dinitrophenol + chloride
-
 ?
4-chlorobenzoate + H2O
-
 Burkholderia sp. 4-hydroxybenzoate + Cl-
-
 ?
4-chlorobenzoate + H2O
-
 Burkholderia sp. LB400 4-hydroxybenzoate + Cl-
-
 ?