Literature summary for 3.8.1.5 extracted from

Kokkonen, P.; Bednar, D.; Dockalova, V.; Prokop, Z.; Damborsky, J.
Conformational changes allow processing of bulky substrates by a haloalkane dehalogenase with a small and buried active site (2018), J. Biol. Chem., 293, 11505-11512 .

Search for more literature for 3.8.1.5

Protein Variants

Protein Variants	Comment	Organism
F172W	the conformational change of the mutant enzyme is faster than that of the wild-type enzyme. The open conformation is more common than the closed one. The closed conformation also displays a larger distance between the two helices than what is observed in the wild-type simulations	Xanthobacter autotrophicus

Organism

Organism	UniProt	Comment	Textmining
Xanthobacter autotrophicus	P22643	-	-
Xanthobacter autotrophicus GJ10	P22643	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1,2-dichloroethane + H2O	-	Xanthobacter autotrophicus	2-chloro-1-ethanol + chloride	-	?
1,2-dichloroethane + H2O	-	Xanthobacter autotrophicus GJ10	2-chloro-1-ethanol + chloride	-	?

Synonyms

Synonyms	Comment	Organism
DhlA	-	Xanthobacter autotrophicus

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Release 2023.1 (January 2023)