Literature summary for 3.8.1.5 extracted from

Gross, J.; Prokop, Z.; Janssen, D.; Faber, K.; Hall, M.
Regio- and enantioselective sequential dehalogenation of rac-1,3-dibromobutane by haloalkane dehalogenase LinB (2016), ChemBioChem, 17, 1437-1441 .

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Organism

Organism	UniProt	Comment	Textmining
Sphingobium indicum	D4Z2G1	-	-
Sphingobium indicum UT26	D4Z2G1	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
rac-1,3-dibromobutane + H2O	hydrolytic dehalogenation of rac-1,3-dibromobutane proceeds in a sequential fashion: initial formation of intermediate haloalcohols followed by a second hydrolytic step to produce the final diol. Intermediate haloalcohols formed with moderate to good enantiomeric excess ((S)-4-bromobutan-2-ol: up to 87%). (S)-butane-1,3-diol is formed at a maximum enantiomeric excess of 35% before full hydrolysis furnished the racemic diol product	Sphingobium indicum	(S)-butane-1,3-diol + bromide	-	?
rac-1,3-dibromobutane + H2O	hydrolytic dehalogenation of rac-1,3-dibromobutane proceeds in a sequential fashion: initial formation of intermediate haloalcohols followed by a second hydrolytic step to produce the final diol. Intermediate haloalcohols formed with moderate to good enantiomeric excess ((S)-4-bromobutan-2-ol: up to 87%). (S)-butane-1,3-diol is formed at a maximum enantiomeric excess of 35% before full hydrolysis furnished the racemic diol product	Sphingobium indicum UT26	(S)-butane-1,3-diol + bromide	-	?

Synonyms

Synonyms	Comment	Organism
haloalkane dehalogenase LinB	-	Sphingobium indicum

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Release 2023.1 (January 2023)