Literature summary for 3.8.1.5 extracted from

Banas, P.; Otyepka, M.; Jerabek, P.; Petrek, M.; Damborsky, J.
Mechanism of enhanced conversion of 1,2,3-trichloropropane by mutant haloalkane dehalogenase revealed by molecular modeling (2006), J. Comput. Aided Mol. Des., 20, 375-383.

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Protein Variants

Protein Variants	Comment	Organism
C176Y	threefold increase in catalytic efficiency for substrate 1,2,3-trichloropropane. Mutation modifies the protein access and export routes	Rhodococcus sp.
C176Y	mutant with a threefold higher catalytic efficiency for 1,2,3-trichloropropane dehalogenation	Rhodococcus sp.

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1,2,3-trichloropropane + H2O	Rhodococcus sp.	-	2,3-dichlorpropane-1-ol + chloride	-	ir

Organism

Organism	UniProt	Comment	Textmining
Rhodococcus sp.	-	recombinant enzyme	-
Rhodococcus sp.	P0A3G3	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1,2,3-trichloropropane + H2O	-	Rhodococcus sp.	2,3-dichloropropan-1-ol + chloride	prefered formation of R-enantiomer due to a specific interaction of substrate with residue N41	?
1,2,3-trichloropropane + H2O	-	Rhodococcus sp.	2,3-dichlorpropane-1-ol + chloride	-	ir

Synonyms

Synonyms	Comment	Organism
DhaA	-	Rhodococcus sp.
haloalkane dehalogenase	-	Rhodococcus sp.

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Release 2023.1 (January 2023)