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Literature summary for 3.7.1.3 extracted from

  • Bouknight, R.R.; Sadoff, H.L.
    Tryptophan catabolism in Bacillus megaterium (1975), J. Bacteriol., 121, 70-76.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.7.1.3

Activating Compound

Activating Compound Comment Organism Structure
additional information kynurenine induces both tryptophan oxygenase and kynureninase of the catabolic pathway of L-tryptophan degradation Priestia megaterium

Inhibitors

Inhibitors Comment Organism Structure
additional information catabolite repression of the pathway by glucose and glutamate, arginine does not cause repression Priestia megaterium

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-kynurenine + H2O Priestia megaterium the enzyme is involved in the catabolic pathway of L-tryptophan degradation, overview anthranilate + L-alanine
-
 ?

Organism

Organism UniProt Comment Textmining
Priestia megaterium
-
 strain ATCC 19213
-

Source Tissue

Source Tissue Comment Organism Textmining
culture condition:L-tryptophan-grown cell cells grown in a medium containing L-tryptophan as the sole carbon, nitrogen, and energy source Priestia megaterium
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 poor activity in cells grown on arginine and on glucose, also in presence of L-tryptophan Priestia megaterium
4.4
-
 cells grown on L-asparagine Priestia megaterium
8.8
-
 cells grown on L-arginine Priestia megaterium
10.3
-
 cells grown on L-alanine Priestia megaterium
31.25
-
 cells grown on L-tryptophan Priestia megaterium

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-kynurenine + H2O
-
 Priestia megaterium anthranilate + L-alanine
-
 ?
L-kynurenine + H2O the enzyme is involved in the catabolic pathway of L-tryptophan degradation, overview Priestia megaterium anthranilate + L-alanine
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Priestia megaterium

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
 assay at Priestia megaterium