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Literature summary for 3.7.1.3 extracted from
- Crystalline inducible kynureninase of Neurospora crassa (1976), FEBS Lett., 70, 235-238.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | tryptophan metabolism | Neurospora crassa |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
- |
Neurospora crassa |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| HgCl2 | - |
Neurospora crassa |  |
| NH2OH | - |
Neurospora crassa | |
| p-chloromercuribenzoate | - |
Neurospora crassa | |
| phenylhydrazine-HCl | - |
Neurospora crassa | |
| Semicarbazide | - |
Neurospora crassa | |
| Sodium borohydride | - |
Neurospora crassa | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.018 | - |
L-kynurenine | - |
Neurospora crassa | |
| 0.035 | - |
L-3-hydroxykynurenine | - |
Neurospora crassa | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 105000 | - |
gel filtration | Neurospora crassa |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3-hydroxy-L-kynurenine + H2O | Neurospora crassa | - |
3-hydroxyanthranilate + L-Ala | - |
? | |
| L-kynurenine + H2O | Neurospora crassa | - |
anthranilate + L-alanine | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Neurospora crassa | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Neurospora crassa |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 2.49 | - |
- |
Neurospora crassa |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3-hydroxy-L-kynurenine + H2O | - |
Neurospora crassa | 3-hydroxyanthranilate + L-alanine | - |
? | |
| 3-hydroxy-L-kynurenine + H2O | - |
Neurospora crassa | 3-hydroxyanthranilate + L-Ala | - |
? | |
| L-kynurenine + H2O | - |
Neurospora crassa | anthranilate + L-alanine | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.5 | - |
- |
Neurospora crassa |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 5.5 | 9.5 | - |
Neurospora crassa |
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Release 2023.1 (January 2023)
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