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Literature summary for 3.7.1.2 extracted from

  • Han, C.; Ren, C.; Zhi, T.; Zhou, Z.; Liu, Y.; Chen, F.; Peng, W.; Xie, D.
    Disruption of fumarylacetoacetate hydrolase causes spontaneous cell death under short-day conditions in Arabidopsis (2013), Plant Physiol., 162, 1956-1964.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.7.1.2

Cloned(Commentary)

Cloned (Comment) Organism
SSCD1 gene, DNA and amino acid sequence determination and analysis, map-based cloning Arabidopsis thaliana

Protein Variants

Protein Variants Comment Organism
additional information isolation and analysis of the sscd1-1 mutant. Generation of the sscd1 hgo double mutant through genetic crossing of sscd1-1 with hgo-1, an inactive homogentisate dioxygenase mutant, phenotypic analysis Arabidopsis thaliana

Inhibitors

Inhibitors Comment Organism Structure
succinylacetone treatment of wild-type seedlings with succinylacetone mimicks the sscd1 phenotypes: the treated wild-type seedlings exhibit wilted leaves and slow-growth symptoms under long-day, these symptoms are more severe under short-day. The sscd1 mutant is more sensitive to succinylacetone than the wild type under long-day Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4-fumarylacetoacetate + H2O Arabidopsis thaliana
-
 acetoacetate + fumarate
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana Q8RW90
-
-

Source Tissue

Source Tissue Comment Organism Textmining
seedling
-
 Arabidopsis thaliana
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-fumarylacetoacetate + H2O
-
 Arabidopsis thaliana acetoacetate + fumarate
-
 ?

Synonyms

Synonyms Comment Organism
FAH
-
 Arabidopsis thaliana

General Information

General Information Comment Organism
malfunction an Arabidopsis thaliana short-day sensitive cell death1 (sscd1) mutant displays a spontaneous cell death phenotype under short-day conditions, disruption of FAH leads to cell death, phenotype overview. The spontaneous cell death phenotype of the sscd1 mutant is completely eliminated by further knockout of the gene encoding the putative homogentisate dioxygenase, which catalyzes homogentisate into maleylacetoacetate (the antepenultimate step) in the Tyr degradation pathway. Treatment of Arabidopsis wild-type seedlings with succinylacetone, an abnormal metabolite caused by loss of FAH in the Tyr degradation pathway, mimicks the sscd1 cell death phenotype Arabidopsis thaliana
metabolism fumarylacetoacetate hydrolase hydrolyzes fumarylacetoacetate to fumarate and acetoacetate, the final step in the tyrosine degradation pathway that is essential for plant survival under short-day conditions Arabidopsis thaliana