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Literature summary for 3.7.1.2 extracted from
- The Caenorhabditis elegans K10C2.4 gene encodes a member of the fumarylacetoacetate hydrolase family: a Caenorhabditis elegans model of type I tyrosinemia (2008), J. Biol. Chem., 283, 9127-9135.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | type I tyrosinemia is caused by mutations in the fumarylacetoacetate hydrolase gene, the results establish worms as a model for the study of type I tyrosinemia | Caenorhabditis elegans |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | RNAi directed against the K10C2.4 gene, encoding fumarylacetoacetate hydrolase, produces a lethal phenotype | Caenorhabditis elegans |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 46000 | - |
predicted molecular weight, verified by SDS-PAGE and Western blot | Caenorhabditis elegans |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-fumarylacetoacetate + H2O | Caenorhabditis elegans | - |
acetoacetate + fumarate | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Caenorhabditis elegans | Q94272 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-fumarylacetoacetate + H2O | - |
Caenorhabditis elegans | acetoacetate + fumarate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| FAH | - |
Caenorhabditis elegans |
| fumarylacetoacetase | - |
Caenorhabditis elegans |
| fumarylacetoacetate hydrolase | - |
Caenorhabditis elegans |
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