Application | Comment | Organism |
---|---|---|
medicine | in humans, deficiency of this activity is associated with the metabolic disease hereditary tyrosinaemia type 1, which is also known as hepatorenal tyrosinaemia | Thermus thermophilus |
Cloned (Comment) | Organism |
---|---|
into the vector pET11a for expression in Escherichia coli BL21DE3 cells | Thermus thermophilus |
Crystallization (Comment) | Organism |
---|---|
a recombinant form of the fumarylacetoacetase family member TTHA0809 from Thermus thermophilus HB8 is crystallized, diffraction data are collected at 2.2 A | Thermus thermophilus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
29400 | - |
determined by SDS-PAGE | Thermus thermophilus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-fumarylacetoacetate + H2O | Thermus thermophilus | - |
acetoacetate + fumarate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Thermus thermophilus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
using a HiPrep 26/10 desalting column, a Super Q Toyopearl 650M column, a Resource Q column, a Bio-Scale CHT-10-I column, and a HiLoad 16/60 Superdex 200 pg column | Thermus thermophilus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-fumarylacetoacetate + H2O | - |
Thermus thermophilus | acetoacetate + fumarate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
FAA | - |
Thermus thermophilus |
fumarylacetoacetase | - |
Thermus thermophilus |
TTHA0809 | - |
Thermus thermophilus |