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Literature summary for 3.7.1.2 extracted from

  • Timm, D.E.; Mueller, H.A.; Bhanumoorthy, P.; Harp, J.M.; Bunick, G.J.
    Crystal structure and mechanism of a carbon-carbon bond hydrolase (1999), Structure, 7, 1023-1033.
    View publication on PubMed

Application

Application Comment Organism
medicine plays a role in hereditary tyrosinemia Mus musculus
medicine plays a role in degradation pathway of phenylalanine and tyrosine Mus musculus

Crystallization (Commentary)

Crystallization (Comment) Organism
-
Mus musculus

Protein Variants

Protein Variants Comment Organism
A134D
-
Mus musculus
C193R mutant may affect the active-site geometry Mus musculus
D233V mutant Mus musculus
G158D mutant may affect the active-site geometry Mus musculus
G158D mutant may affect the active site by perturbing the FAH quarternary structure Mus musculus
G207D mutant may affect the active-site geometry Mus musculus
G369V mutant may affect the active-site geometry Mus musculus
N16I mutant may disrupt activity by causing misfolding Mus musculus
P249T mutant may affect the active-site geometry Mus musculus
P261L mutant may cause general structural effects or misfolding by disrupting the hydrophobic core, the native mainchain conformation and/or important electrostatic interactions Mus musculus
P342L mutant may cause general structural effects or misfolding by disrupting the hydrophobic core, the native mainchain conformation and/or important electrostatic interactions Mus musculus
S405H mutant may cause general structural effects or misfolding by disrupting the hydrophobic core, the native mainchain conformation and/or important electrostatic interactions Mus musculus
V166G mutant may affect the active-site geometry Mus musculus
W234G mutant may affect the active-site geometry Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+
-
Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
46000
-
2 * 46000 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4-fumarylacetoacetate + H2O Mus musculus
-
acetoacetate + fumarate
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-fumarylacetoacetate + H2O
-
Mus musculus acetoacetate + fumarate
-
?

Subunits

Subunits Comment Organism
dimer 2 * 46000 Mus musculus