Literature summary for 3.7.1.2 extracted from

Nagainis, M.P.; Pu, W.; Cheng, B.; Taylor, K.E.; Schmidt, Jr., D.E.
Effects of pH and sulfhydryl specific reagents on 4-fumarylacetoacetate fumarylhydrolase (1981), Biochim. Biophys. Acta, 657, 203-211.

Search for more literature for 3.7.1.2

Application

Application	Comment	Organism
medicine	plays a role in hereditary tyrosinemia	Bos taurus
medicine	plays a role in degradation pathway of phenylalanine and tyrosine	Bos taurus

Inhibitors

Inhibitors	Comment	Organism	Structure
5,5'-dithiobis(2-nitrobenzoic acid)	-	Bos taurus
p-hydroxymercuribenzoate	-	Bos taurus

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
2.3	6	propionopyruvate	dependent on pH	Bos taurus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
intracellular	-	Bos taurus	5622	-

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
87000	-	gel filtration	Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
4-fumarylacetoacetate + H2O	Bos taurus	-	acetoacetate + fumarate	-	?

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Bos taurus

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Bos taurus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4-fumarylacetoacetate + H2O	-	Bos taurus	acetoacetate + fumarate	-	?
propionopyruvate + H2O	-	Bos taurus	?	-	?

Subunits

Subunits	Comment	Organism
dimer	2 * 40000-43000, gel filtration	Bos taurus

pH Range

pH Minimum	pH Maximum	Comment	Organism
6.25	8.5	-	Bos taurus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)