Inhibitors | Comment | Organism | Structure |
---|---|---|---|
tubulin | unassembled tubulin denatures relatively easily, and the denatured tubulin can inhibit the assembly itself | Mus musculus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
49800 | - |
theoretical molecular mass, beta tubulin | Mus musculus |
49800 | - |
theoretical molecular mass, beta tubulin | Bos taurus |
50000 | - |
alpha-beta tubulin | Bos taurus |
50000 | - |
determined by SDS-PAGE and immunoblot analysis | Mus musculus |
50130 | - |
theoretical molecular mass, alpha tubulin | Mus musculus |
50130 | - |
theoretical molecular mass, alpha tubulin | Bos taurus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + H2O | Mus musculus | - |
GDP + phosphate | - |
ir | |
GTP + H2O | Bos taurus | - |
GDP + phosphate | - |
ir |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Mus musculus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
microtubules are prepared from freshly isolated lens epithelial fractions from mice | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Bos taurus | - |
lens | lens epithelial cell | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + H2O | - |
Mus musculus | GDP + phosphate | - |
ir | |
GTP + H2O | - |
Bos taurus | GDP + phosphate | - |
ir |
Subunits | Comment | Organism |
---|---|---|
heterodimer | - |
Mus musculus |
heterodimer | - |
Bos taurus |
More | elongated microtubule protofilaments form at 37°C in the presence of GTP and later close into hollow cylindrical polymers | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
tubulin GTPase | - |
Mus musculus |
tubulin GTPase | - |
Bos taurus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
elongated microtubule protofilaments form at 37°C in the presence of GTP and later close into hollow cylindrical polymers | Mus musculus |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0077 | - |
GTP | in the presence of alphaA-crystallin | Bos taurus | |
0.008 | - |
GTP | in the presence of alphaB-crystallin | Bos taurus | |
0.0083 | - |
GTP | - |
Bos taurus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.8 | - |
assembly of microtubules | Mus musculus |