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Literature summary for 3.6.5.6 extracted from
- Molecular dissection of GTP exchange and hydrolysis within the ternary complex of tubulin heterodimers and Op18/stathmin family members (2003), J. Biol. Chem., 278, 16651-16657.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| GTP + H2O = GDP + phosphate | mechanism | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GTP + H2O | - |
Homo sapiens | GDP + phosphate | - |
? |  |
| additional information | GTP hydrolysis occurs at a single exchangeable GTP-binding site which is at the interface between head-to-tail arranged heterodimer enzyme | Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | proteins Op18, RB3 and SCG10 of the oncoprotein18/stathmin family bind and stimulate enzyme at a low and indistinguishable rate of GTP hydrolysis, complex of enzyme and proteins may prevent futile cycles of GTP hydrolysis | Homo sapiens |
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