Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,5-bis(2-(dimethylamino)ethylamino)-1,4-benzoquinone | - |
Ovis aries | |
2,5-bis(2-(hydroxymethyl)anilino)-1,4-benzoquinone | - |
Ovis aries | |
2,5-bis(2-bromoanilino)-1,4-benzoquinone | - |
Ovis aries | |
2,5-bis(2-carboxyanilino)-1,4-benzoquinone | - |
Ovis aries | |
2,5-bis(3-bromopropylamino)-1,4-benzoquinone | - |
Ovis aries | |
2,5-bis(3-carboxyanilino)-1,4-benzoquinone | - |
Ovis aries | |
2,5-bis(3-hydroxyanilino)-1,4-benzoquinone | - |
Ovis aries | |
2,5-bis(3-methoxyanilino)-1,4-benzoquinone | - |
Ovis aries | |
2,5-bis(3-methoxypropylamino)-1,4-benzoquinone | - |
Ovis aries | |
2,5-bis(4-(hydroxymethyl)phenylamino)-1,4-benzoquinone | - |
Ovis aries | |
2,5-bis(4-carboxyanilino)-1,4-benzoquinone | - |
Ovis aries | |
2,5-bis(4-carboxybenzylamino)-1,4-benzoquinone | - |
Ovis aries | |
2,5-bis(4-hydroxyanilino)-1,4-benzoquinone | - |
Ovis aries | |
2,5-bis(4-hydroxybenzylamino)-1,4-benzoquinone | - |
Ovis aries | |
2,5-bis(4-methoxyanilino)-1,4-benzoquinone | - |
Ovis aries | |
2,5-bis(4-methoxybenzylamino)-1,4-benzoquinone | - |
Ovis aries | |
2,5-bis(hexylamino)-1,4-benzoquinone | - |
Ovis aries | |
2,5-bis(phenylamino)-1,4-benzoquinone | - |
Ovis aries | |
2,5-bis-(benzylamino)-1,4-benzoquinone | - |
Ovis aries | |
2-(2-carboxyanilino)-1,4-naphthoquinone | - |
Ovis aries | |
2-(3-(hydroxymethyl)anilino)-1,4-naphthoquinone | - |
Ovis aries | |
2-(3-hydroxyanilino)-1,4-naphthoquinone | - |
Ovis aries | |
2-(4-(hydroxymethyl)anilino)-1,4-naphthoquinone | - |
Ovis aries | |
2-(4-hydroxyanilino)-1,4-naphthoquinone | - |
Ovis aries | |
2-(4-hydroxybenzylamino)-1,4-naphthoquinone | - |
Ovis aries | |
additional information | development of quinone analogues as dynamin GTPase inhibitors, docking study and molecular modelling, overview. No or poor inhibition by 2,5-bis(2-methylanilino)-1,4-benzoquinone, 2,5-bis(2-methoxyanilino)-1,4-benzoquinone, 2,5-bis(3-(hydroxymethyl)phenylamino)-1,4-benzoquinone, 2,5-b+F49is(2-hydroxyethylamino)-1,4-benzoquinone, 2,5-bis(3-hydroxypropylamino)-1,4-benzoquinone, 2,5-bis(4-hydroxybutylamino)-1,4-benzoquinone, 2,5-bis(2-methoxyethylamino)-1,4-benzoquinone, 2,5-bis(2-(methylthio)ethylamino)-1,4-benzoquinone, 2,5-bis(2-chloroethylamino)-1,4-benzoquinone, 2,5-bis(2-bromoethylamino)-1,4-benzoquinone, 2,5-bis(3-chloropropylamino)-1,4-benzoquinone, 2,5-bis(3-pyridylmethylamino)-1,4-benzoquinone, 2,5-bis(4-methylbenzylamino)-1,4-benzoquinone, 2,5-bis(4-fluorobenzylamino)-1,4-benzoquinone, 2,5-bis(4-bromobenzylamino)-1,4-benzoquinone, 2,5-bis(4-chlorobenzylamino)-1,4-benzoquinone, 2,5-bis(phenethylamino)-1,4-benzoquinone, 2,5-bis(ethylamino)-1,4-benzoquinone, 2,5-bis(propylamino)-1,4-benzoquinone, 2,5-bis(butylamino)-1,4-benzoquinone, 2,5-bis(pentylamino)-1,4-benzoquinone, 2,5-bis(isopentylamino)-1,4-benzoquinone, 2,5-bis(allylamino)-1,4-benzoquinone, 2-(2-hydroxyethylamino)-1,4-naphthoquinone, 2-(3-hydroxypropylamino)-1,4-naphthoquinone, 2-(anilino)-1,4-naphthoquinone, 2-(3-carboxyanilino)-1,4-naphthoquinone, 2-(4-carboxyanilino)-1,4-naphthoquinone, 2-(benzylamino)-1,4-naphthoquinone, and 2-(4-methoxybenzylamino)-1,4-naphthoquinone | Ovis aries |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | peripheral membrane fraction | Ovis aries | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Ovis aries |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + H2O | Ovis aries | - |
GDP + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Ovis aries | - |
- |
- |
Purification (Comment) | Organism |
---|---|
native enzyme from sheep brain membrane fraction by affinity chromatography | Ovis aries |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Ovis aries | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + H2O | - |
Ovis aries | GDP + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
dynamin GTPase | - |
Ovis aries |
dynamin I GTPase | - |
Ovis aries |
dynI GTPase | - |
Ovis aries |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0106 | - |
pH and temperature not specified in the publication | Ovis aries | 2,5-bis(4-carboxyanilino)-1,4-benzoquinone | |
0.0111 | - |
pH and temperature not specified in the publication | Ovis aries | 2,5-bis(4-hydroxyanilino)-1,4-benzoquinone | |
0.0215 | - |
pH and temperature not specified in the publication | Ovis aries | 2,5-bis(4-(hydroxymethyl)phenylamino)-1,4-benzoquinone | |
0.0224 | - |
pH and temperature not specified in the publication | Ovis aries | 2-(4-hydroxyanilino)-1,4-naphthoquinone | |
0.0254 | - |
pH and temperature not specified in the publication | Ovis aries | 2,5-bis(3-carboxyanilino)-1,4-benzoquinone | |
0.029 | - |
pH and temperature not specified in the publication | Ovis aries | 2,5-bis(4-carboxybenzylamino)-1,4-benzoquinone | |
0.0295 | - |
pH and temperature not specified in the publication | Ovis aries | 2-(4-(hydroxymethyl)anilino)-1,4-naphthoquinone | |
0.0303 | - |
pH and temperature not specified in the publication | Ovis aries | 2-(3-(hydroxymethyl)anilino)-1,4-naphthoquinone | |
0.0502 | - |
pH and temperature not specified in the publication | Ovis aries | 2,5-bis(2-carboxyanilino)-1,4-benzoquinone | |
0.0579 | - |
pH and temperature not specified in the publication | Ovis aries | 2,5-bis(3-hydroxyanilino)-1,4-benzoquinone | |
0.109 | - |
pH and temperature not specified in the publication | Ovis aries | 2-(3-hydroxyanilino)-1,4-naphthoquinone | |
0.112 | - |
pH and temperature not specified in the publication | Ovis aries | 2,5-bis(4-hydroxybenzylamino)-1,4-benzoquinone | |
0.116 | - |
pH and temperature not specified in the publication | Ovis aries | 2,5-bis(3-methoxypropylamino)-1,4-benzoquinone | |
0.15 | - |
pH and temperature not specified in the publication | Ovis aries | 2-(4-hydroxybenzylamino)-1,4-naphthoquinone | |
0.17 | - |
pH and temperature not specified in the publication | Ovis aries | 2,5-bis(4-methoxybenzylamino)-1,4-benzoquinone | |
0.273 | - |
pH and temperature not specified in the publication | Ovis aries | 2,5-bis-(benzylamino)-1,4-benzoquinone | |
0.3 | - |
pH and temperature not specified in the publication | Ovis aries | 2,5-bis(hexylamino)-1,4-benzoquinone | |
0.3 | - |
pH and temperature not specified in the publication | Ovis aries | 2,5-bis(2-(dimethylamino)ethylamino)-1,4-benzoquinone | |
0.3 | - |
pH and temperature not specified in the publication | Ovis aries | 2,5-bis(3-methoxyanilino)-1,4-benzoquinone | |
0.3 | - |
pH and temperature not specified in the publication | Ovis aries | 2,5-bis(4-methoxyanilino)-1,4-benzoquinone | |
0.3 | - |
pH and temperature not specified in the publication | Ovis aries | 2,5-bis(2-(hydroxymethyl)anilino)-1,4-benzoquinone | |
0.314 | - |
pH and temperature not specified in the publication | Ovis aries | 2-(2-carboxyanilino)-1,4-naphthoquinone | |
0.387 | - |
pH and temperature not specified in the publication | Ovis aries | 2,5-bis(2-bromoanilino)-1,4-benzoquinone | |
0.58 | - |
pH and temperature not specified in the publication | Ovis aries | 2,5-bis(3-bromopropylamino)-1,4-benzoquinone |