Cloned (Comment) | Organism |
---|---|
expression of GFP-tagged or V5/His-tagged wild-type and K44A mutant dynamin 2aa in HeLa cells | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
K44A | a dominant-negative mutation, blocks cytokinesis and membrane trafficking, but does not affect endocytosis, the mutant has no effect on microtubules | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microtubule | dynamin 2 | Rattus norvegicus | 5874 | - |
additional information | localization of dynamin 2 depends on its Pro-rich domain, immunohistochemic determination of dynamin 2 localization during mitosis, overview | Rattus norvegicus | - |
- |
spindle | dynamin 2 | Rattus norvegicus | 5819 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
dynamin 2 | - |
Rattus norvegicus |
dynamin 2aa | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
malfunction | deletion of dynamin middle domain blocks binding to gamma-tubulin and impairs entry into mitosis, but does not affect endocytosis | Rattus norvegicus |
physiological function | dynamin 2 GTPase is a key player in membrane traffic and clathrin-mediated endocytosis, molecular mechanism, overview. It also regulates the dynamic instability of microtubules by a membrane traffic-independent mechanism. Dynamin may play a key role in cell cycle progression by regulating the microtubules | Rattus norvegicus |