Cloned (Comment) | Organism |
---|---|
expressed in a fibroblastoid cell line and in embryonic stem cells | Rattus norvegicus |
expressed in a fibroblastoid cell line and in embryonic stem cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
K44A | dominant-negative dynamin mutant | Rattus norvegicus |
K44A | dominant-negative dynamin mutant | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | dynamin 2 is specifically required for clathrin-mediated endocytosis in fibroblastoid cells, p75 export from the Golgi, and PDGF-stimulated macropinocytosis and cytokinesis, but not for other endocytic pathways, clathrin-mediated endocytosis and p75 exocytosis are efficiently rescued by reintroduction of dynamin 2, but not dynamin 1, suggesting that these two isoforms function differentially in vesicular trafficking in nonneuronal cells. Both isoforms rescue macropinocytosis and cytokinesis, suggesting that dynamin function in these processes may be mechanistically distinct from its role in clathrin-mediated endocytosis. Although all four dynamin 2 splice variants can equally restore clathrin-mediated endocytosis, dynamin 2ba and dynamin 2bb are more effective at restoring p75 exocytosis. | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q05193 | - |
- |
Rattus norvegicus | P21575 | - |
- |
Rattus norvegicus | P39052 | - |
- |
Rattus norvegicus | Q08877 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + H2O | - |
Rattus norvegicus | GDP + phosphate | - |
? | |
GTP + H2O | - |
Homo sapiens | GDP + phosphate | - |
? | |
additional information | dynamin 2 is specifically required for clathrin-mediated endocytosis in fibroblastoid cells, p75 export from the Golgi, and PDGF-stimulated macropinocytosis and cytokinesis, but not for other endocytic pathways, clathrin-mediated endocytosis and p75 exocytosis are efficiently rescued by reintroduction of dynamin 2, but not dynamin 1, suggesting that these two isoforms function differentially in vesicular trafficking in nonneuronal cells. Both isoforms rescue macropinocytosis and cytokinesis, suggesting that dynamin function in these processes may be mechanistically distinct from its role in clathrin-mediated endocytosis. Although all four dynamin 2 splice variants can equally restore clathrin-mediated endocytosis, dynamin 2ba and dynamin 2bb are more effective at restoring p75 exocytosis. | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Dyn | - |
Rattus norvegicus |
Dyn | - |
Homo sapiens |
Dyn1 | isoform | Rattus norvegicus |
Dyn1 | isoform | Homo sapiens |
DYN2 | isoform | Rattus norvegicus |
Dyn2ba | splice variant | Rattus norvegicus |
Dyn2bb | splice variant | Rattus norvegicus |
Dyn3 | isoform | Rattus norvegicus |
dynamin | - |
Rattus norvegicus |
dynamin | - |
Homo sapiens |