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Literature summary for 3.6.5.5 extracted from

  • Liu, Y.W.; Surka, M.C.; Schroeter, T.; Lukiyanchuk, V.; Schmid, S.L.
    Isoform and splice-variant specific functions of dynamin-2 revealed by analysis of conditional knock-out cells (2008), Mol. Biol. Cell, 19, 5347-5359.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.6.5.5

Cloned(Commentary)

Cloned (Comment) Organism
expressed in a fibroblastoid cell line and in embryonic stem cells Rattus norvegicus
expressed in a fibroblastoid cell line and in embryonic stem cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
K44A dominant-negative dynamin mutant Rattus norvegicus
K44A dominant-negative dynamin mutant Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus dynamin 2 is specifically required for clathrin-mediated endocytosis in fibroblastoid cells, p75 export from the Golgi, and PDGF-stimulated macropinocytosis and cytokinesis, but not for other endocytic pathways, clathrin-mediated endocytosis and p75 exocytosis are efficiently rescued by reintroduction of dynamin 2, but not dynamin 1, suggesting that these two isoforms function differentially in vesicular trafficking in nonneuronal cells. Both isoforms rescue macropinocytosis and cytokinesis, suggesting that dynamin function in these processes may be mechanistically distinct from its role in clathrin-mediated endocytosis. Although all four dynamin 2 splice variants can equally restore clathrin-mediated endocytosis, dynamin 2ba and dynamin 2bb are more effective at restoring p75 exocytosis. ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q05193
-
-
Rattus norvegicus P21575
-
-
Rattus norvegicus P39052
-
-
Rattus norvegicus Q08877
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + H2O
-
 Rattus norvegicus GDP + phosphate
-
 ?
GTP + H2O
-
 Homo sapiens GDP + phosphate
-
 ?
additional information dynamin 2 is specifically required for clathrin-mediated endocytosis in fibroblastoid cells, p75 export from the Golgi, and PDGF-stimulated macropinocytosis and cytokinesis, but not for other endocytic pathways, clathrin-mediated endocytosis and p75 exocytosis are efficiently rescued by reintroduction of dynamin 2, but not dynamin 1, suggesting that these two isoforms function differentially in vesicular trafficking in nonneuronal cells. Both isoforms rescue macropinocytosis and cytokinesis, suggesting that dynamin function in these processes may be mechanistically distinct from its role in clathrin-mediated endocytosis. Although all four dynamin 2 splice variants can equally restore clathrin-mediated endocytosis, dynamin 2ba and dynamin 2bb are more effective at restoring p75 exocytosis. Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
Dyn
-
 Rattus norvegicus
Dyn
-
 Homo sapiens
Dyn1 isoform Rattus norvegicus
Dyn1 isoform Homo sapiens
DYN2 isoform Rattus norvegicus
Dyn2ba splice variant Rattus norvegicus
Dyn2bb splice variant Rattus norvegicus
Dyn3 isoform Rattus norvegicus
dynamin
-
 Rattus norvegicus
dynamin
-
 Homo sapiens