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Literature summary for 3.6.5.5 extracted from

  • Soulet, F.; Schmid, S.L.; Damke, H.
    Domain requirements for an endocytosis-independent, isoform-specific function of dynamin-2 (2006), Exp. Cell Res., 312, 3539-3545.
    View publication on PubMed
Search for more literature for 3.6.5.5

Cloned(Commentary)

Cloned (Comment) Organism
the vectors pcDNA3.1 and pADT3T7tet are used, recombinant adenoviruses are produced in HEK293-Cre cells Homo sapiens
the vectors pcDNA3.1 and pADT3T7tet are used, recombinant adenoviruses are produced in HEK293-Cre cells Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
Dyn2DELTAPRD truncation mutant lacking the C-terminal proline-arginine-rich domain, PRD Rattus norvegicus
Dyn2I684K point mutation to render Dyn2 defective in oligomerization and self-assembly Rattus norvegicus
Dyn2I684KDELTAPRD point mutation to render Dyn2 defective in oligomerization and self-assembly Rattus norvegicus
Dyn2S45N point mutation to render Dyn2 defective in GTP binding Rattus norvegicus
Dyn2S45N/I684K point mutations to render Dyn2 defective in GTP binding and in oligomerization and self-assembly Rattus norvegicus
DynII690K point mutation to render Dyn1 defective in oligomerization and self-assembly Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP + H2O Homo sapiens
-
 GDP + phosphate
-
 ir
GTP + H2O Rattus norvegicus
-
 GDP + phosphate
-
 ir

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + H2O
-
 Homo sapiens GDP + phosphate
-
 ir
GTP + H2O
-
 Rattus norvegicus GDP + phosphate
-
 ir

Subunits

Subunits Comment Organism
heterotetramer Dyn1 can interfere with Dyn2 or Dyn2 mutants, Dyn2-Dyn1, Dyn2S45N-Dyn1 and Dyn2-Dyn1I690K heteromers are formed Homo sapiens
heterotetramer Dyn2 can interfere with Dyn2 mutants or Dyn1, Dyn2-Dyn1, Dyn2S45N-Dyn1 and Dyn2-Dyn1I690K heteromers are formed Rattus norvegicus
homotetramer
-
 Homo sapiens
homotetramer
-
 Rattus norvegicus

Synonyms

Synonyms Comment Organism
dynamin GTPase
-
 Homo sapiens
dynamin GTPase
-
 Rattus norvegicus
dynamin-1 human dynamin-1aa splice variant Homo sapiens
dynamin-2 rat dynamin-2ba splice variant Rattus norvegicus