Literature summary for 3.6.5.5 extracted from

Barsoum, M.J.; Yuan, H.; Gerencser, A.A.; Liot, G.; Kushnareva, Y.; Graeber, S.; Kovacs, I.; Lee, W.D.; Waggoner, J.; Cui, J.; White, A.D.; Bossy, B.; Martinou, J.C.; Youle, R.J.; Lipton, S.A.; Ellisman, M.H.; Perkins, G.A.; Bossy-Wetzel, E.
Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons (2006), EMBO J., 25, 3900-3911.

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Application

Application	Comment	Organism
medicine	it is shown that mitochondrial fission plays a causal role in neuronal demise, blocking fission by dominant-negative mutant Drp1K38A prevents mitochondrial fragmentation and rescues neurons from degeneration and cell death evoked by NO or rotenone	Rattus norvegicus
medicine	mitochondrial fission plays a causal role in neuronal demise, blocking fission by wild-type Mfn1 prevents mitochondrial fragmentation and rescues neurons from degeneration and cell death evoked by NO or rotenone	Rattus norvegicus

Protein Variants

Protein Variants	Comment	Organism
K38A	dominant-negative mutant	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	-	Rattus norvegicus	5737	-
mitochondrial inner membrane	Drp1 assembles into large complexes at future scission sites on the inner mitochondrial membrane	Rattus norvegicus	5743	-
mitochondrial outer membrane	Drp1 binds to mitochondrial outer membrane via Fis1	Rattus norvegicus	5741	-
mitochondrion	-	Rattus norvegicus	5739	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
GTP + H2O	Rattus norvegicus	-	GDP + phosphate	-	ir

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
neuron	cortical neuron	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
GTP + H2O	-	Rattus norvegicus	GDP + phosphate	-	ir

Synonyms

Synonyms	Comment	Organism
Drp1	-	Rattus norvegicus
dynamin GTPase	-	Rattus norvegicus
dynamine-related GTPase	-	Rattus norvegicus
GTPase dynamin-related protein 1	-	Rattus norvegicus
Mfn1	-	Rattus norvegicus
mitofusin 1	-	Rattus norvegicus

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Release 2023.1 (January 2023)