Application | Comment | Organism |
---|---|---|
medicine | it is shown that mitochondrial fission plays a causal role in neuronal demise, blocking fission by dominant-negative mutant Drp1K38A prevents mitochondrial fragmentation and rescues neurons from degeneration and cell death evoked by NO or rotenone | Rattus norvegicus |
medicine | mitochondrial fission plays a causal role in neuronal demise, blocking fission by wild-type Mfn1 prevents mitochondrial fragmentation and rescues neurons from degeneration and cell death evoked by NO or rotenone | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
K38A | dominant-negative mutant | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Rattus norvegicus | 5737 | - |
mitochondrial inner membrane | Drp1 assembles into large complexes at future scission sites on the inner mitochondrial membrane | Rattus norvegicus | 5743 | - |
mitochondrial outer membrane | Drp1 binds to mitochondrial outer membrane via Fis1 | Rattus norvegicus | 5741 | - |
mitochondrion | - |
Rattus norvegicus | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + H2O | Rattus norvegicus | - |
GDP + phosphate | - |
ir |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neuron | cortical neuron | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + H2O | - |
Rattus norvegicus | GDP + phosphate | - |
ir |
Synonyms | Comment | Organism |
---|---|---|
Drp1 | - |
Rattus norvegicus |
dynamin GTPase | - |
Rattus norvegicus |
dynamine-related GTPase | - |
Rattus norvegicus |
GTPase dynamin-related protein 1 | - |
Rattus norvegicus |
Mfn1 | - |
Rattus norvegicus |
mitofusin 1 | - |
Rattus norvegicus |