Activating Compound | Comment | Organism | Structure |
---|---|---|---|
lipid tubule | stimulate GTPase activity | Rattus norvegicus |
Crystallization (Comment) | Organism |
---|---|
hanging-drop method, 1.9 A crystal structure of the nucleotide-free GTPase domain of dynamin 1 | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
R59A | kcat is 1.5fold lower than wild-type value, KM is 5.2fold higher than wild-type value | Rattus norvegicus |
R59K | kcat is 3fold lower than wild-type value, KM is 2fold higher than wild-type value | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.046 | - |
GTP | 37°C, wild-type enzyme | Rattus norvegicus | |
0.096 | - |
GTP | 37°C, mutant enzyme R59K | Rattus norvegicus | |
0.241 | - |
GTP | 37°C, mutant enzyme R59A | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + H2O | Rattus norvegicus | - |
GDP + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + H2O | - |
Rattus norvegicus | GDP + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
dynamin 1 | - |
Rattus norvegicus |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0079 | - |
GTP | 37°C, mutant enzyme R59K | Rattus norvegicus | |
0.016 | - |
GTP | 37°C, mutant enzyme R59A | Rattus norvegicus | |
0.024 | - |
GTP | 37°C, wild-type enzyme | Rattus norvegicus |