Cloned (Comment) | Organism |
---|---|
expression of wild-type and K44A mutant dynamin in HeLa cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
K44A | mutant defective in GTP binding and hydrolysis, the Trypanosoma cruzi invasion of nonphagocytic cells is completely abolished by overexpression of the dominant negative mutant of dynamin K44A | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + H2O | Homo sapiens | plays a role in clathrin-mediated endocytosis, the endocytically active GTPase dynamin plays a role in the regulation of Trypanosoma cruzi invasion of nonphagocytic cells, dynamin acts as a limiting factor in allowing trypomastigotes to invade host cells | GDP + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + H2O | - |
Homo sapiens | GDP + phosphate | - |
? | |
GTP + H2O | plays a role in clathrin-mediated endocytosis, the endocytically active GTPase dynamin plays a role in the regulation of Trypanosoma cruzi invasion of nonphagocytic cells, dynamin acts as a limiting factor in allowing trypomastigotes to invade host cells | Homo sapiens | GDP + phosphate | - |
? |