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Literature summary for 3.6.5.5 extracted from

  • Wilkowsky, S.E.; Barbieri, M.A.; Stahl, P.D.; Isola, E.L.D.
    Regulation of Trypanosoma cruzi invasion of nonphagocytic cells by the endocytically active GTPases dynamin, Rab5, and Rab7 (2002), Biochem. Biophys. Res. Commun., 291, 516-521.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression of wild-type and K44A mutant dynamin in HeLa cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
K44A mutant defective in GTP binding and hydrolysis, the Trypanosoma cruzi invasion of nonphagocytic cells is completely abolished by overexpression of the dominant negative mutant of dynamin K44A Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP + H2O Homo sapiens plays a role in clathrin-mediated endocytosis, the endocytically active GTPase dynamin plays a role in the regulation of Trypanosoma cruzi invasion of nonphagocytic cells, dynamin acts as a limiting factor in allowing trypomastigotes to invade host cells GDP + phosphate
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
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Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + H2O
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Homo sapiens GDP + phosphate
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GTP + H2O plays a role in clathrin-mediated endocytosis, the endocytically active GTPase dynamin plays a role in the regulation of Trypanosoma cruzi invasion of nonphagocytic cells, dynamin acts as a limiting factor in allowing trypomastigotes to invade host cells Homo sapiens GDP + phosphate
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?