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Literature summary for 3.6.5.4 extracted from
- Nucleotide-dependent binding of the GTPase domain of the signal recognition particle receptor beta-subunit to the alpha-subunit (2000), J. Biol. Chem., 275, 27439-27446.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | protein translocation across the endoplasmic reticulum | Canis lupus familiaris |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Canis lupus familiaris |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| D181N | hydrolysis of XTP favored over GTP | Canis lupus familiaris |
| G118L | hydrolysis of XTP favored over GTP | Canis lupus familiaris |
| G118L/D181N | hydrolysis of XTP favored over GTP | Canis lupus familiaris |
| H119L | hydrolysis of XTP favored over GTP | Canis lupus familiaris |
| K751/H119L | hydrolysis of XTP favored over GTP | Canis lupus familiaris |
| K75I | hydrolysis of XTP favored over GTP | Canis lupus familiaris |
| additional information | SRbetaC1-deltaTM, hydrolysis of XTP favored over GTP | Canis lupus familiaris |
| additional information | SRbetaD4, hydrolysis of XTP favored over GTP | Canis lupus familiaris |
| additional information | SRbetaD5, hydrolysis of XTP favored over GTP | Canis lupus familiaris |
| additional information | SRbeta-deltaloop, hydrolysis of XTP favored over GTP | Canis lupus familiaris |
| additional information | SRbeta-deltaTM, hydrolysis of XTP favored over GTP | Canis lupus familiaris |
| additional information | Srbeta-loop2, hydrolysis of XTP favored over GTP | Canis lupus familiaris |
| N178K | hydrolysis of XTP favored over GTP | Canis lupus familiaris |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endoplasmic reticulum | SRP receptor alpha and beta subunits | Canis lupus familiaris | 5783 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GTP + H2O | Canis lupus familiaris | - |
GDP + phosphate | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Canis lupus familiaris | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Canis lupus familiaris |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GTP + H2O | - |
Canis lupus familiaris | GDP + phosphate | - |
? | |
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Release 2023.1 (January 2023)
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