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Literature summary for 3.6.5.3 extracted from

  • Satpati, P.; Clavaguera, C.; Ohanessian, G.; Simonson, T.
    Free energy simulations of a GTPase: GTP and GDP binding to archaeal initiation factor 2 (2011), J. Phys. Chem. B, 115, 6749-6763.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.6.5.3

Crystallization (Commentary)

Crystallization (Comment) Organism
analysis of crystal structures of ON and OFF aIF2 at resolution of 3.0 and 2.15 A Saccharolobus solfataricus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information substrate and product binding kinetics and thermodynamics with ON and OFF aIF2 , overview Saccharolobus solfataricus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Saccharolobus solfataricus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP + H2O Saccharolobus solfataricus
-
 GDP + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharolobus solfataricus Q980A5
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + H2O
-
 Saccharolobus solfataricus GDP + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
aIF2
-
 Saccharolobus solfataricus
archaeal initiation factor 2
-
 Saccharolobus solfataricus

General Information

General Information Comment Organism
additional information protein:ligand interactions and conformational changes by molecular dynamics and Monte Carlo simulations, overview Saccharolobus solfataricus
physiological function archaeal initiation factor 2 is a protein involved in the initiation of protein biosynthesis. In its GTP-bound, ON conformation, aIF2 binds an initiator tRNA and carries it to the ribosome. In its GDP-bound, OFF conformation, it dissociates from tRNA, molecular dynamics, overview. AIF2 is largely responsible for recruiting the first, initiator tRNA to the ribosome and positioning it correctly, in register with the start codon of the ribosome-bound mRNA Saccharolobus solfataricus