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Literature summary for 3.6.5.2 extracted from

  • Miura, Y.; Kanaho, Y.
    ACAP3, the GTPase-activating protein specific to the small GTPase Arf6, regulates neuronal migration in the developing cerebral cortex (2017), Biochem. Biophys. Res. Commun., 493, 1089-1094 .
    View publication on PubMed
Search for more literature for 3.6.5.2

Activating Compound

Activating Compound Comment Organism Structure
ACAP3 aGTPase-activating protein (GAP) specific to small GTPase Arf6. ACAP3 is involved in neuronal migration in the developing cerebral cortex of mice, regulation mechanism, detailed overview. ACAP3 is abundantly expressed in the developing cerebral cortex. GAP activity of ACAP3 is required for neuronal migration. Knockdown of ACAP3 in the developing cortical neurons of mice in utero significantly abrogates neuronal migration in the cortical layer, which is restored by ectopic expression of wild-type ACAP3, but not by its GAP-inactive mutant Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP + H2O Mus musculus
-
 GDP + phosphate
-
 ?
GTP + H2O Mus musculus C57BL/6J
-
 GDP + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus P62331
-
-
Mus musculus C57BL/6J P62331
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cerebral cortex of E17 mice Mus musculus
-
hippocampus of E17 mice Mus musculus
-
neuron
-
 Mus musculus
-
olfactory bulb of E17 mice Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + H2O
-
 Mus musculus GDP + phosphate
-
 ?
GTP + H2O
-
 Mus musculus C57BL/6J GDP + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
ADP-ribosylation factor 6 UniProt Mus musculus
Arf6
-
 Mus musculus
small GTPase
-
 Mus musculus

General Information

General Information Comment Organism
evolution Arf6 is a member of the Arf family of small GTPases Mus musculus
metabolism ACAP3, the GTPase-activating protein specific to the small GTPase Arf6, regulates neuronal migration in the developing cerebral cortex. ACAP3 is involved in neuronal migration in the developing cerebral cortex of mice. Knockdown of ACAP3 in the developing cortical neurons of mice in utero significantly abrogates neuronal migration in the cortical layer, which is restored by ectopic expression of wild-type ACAP3, but not by its GAP-inactive mutant Mus musculus
physiological function Arf6 is a critical regulator of membrane dynamics-based cellular events such as reorganization of actin cytoskeleton and membrane trafficking. Like other small GTPases, Arf6 acts as a molecular switch by cycling between GDP-bound inactive and GTP-bound active forms in cellular signaling pathways. Arf6 is activated in response to agonist stimulation of the cell interacts with its downstream effectors to regulate their intracellular location and activity Mus musculus