Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + H2O | Drosophila melanogaster | - |
GDP + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | P08645 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
eye | the enzyme is expressed in the R7 photoreceptor, localization study, overview | Drosophila melanogaster | - |
photoreceptor cell | - |
Drosophila melanogaster | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + H2O | - |
Drosophila melanogaster | GDP + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
RAP | - |
Drosophila melanogaster |
small GTPase | - |
Drosophila melanogaster |
General Information | Comment | Organism |
---|---|---|
evolution | the enzyme belongs to the Ras superfamily | Drosophila melanogaster |
metabolism | photoreceptor R7 is specified by the combined actions of the receptor tyrosine kinase (RTK) and Notch (N) signaling pathways. These pathways interact in a complex manner that includes antagonistic effects on photoreceptor specification and involve the small GTPase Rap. RTK promotes the photoreceptor fate, whereas N inhibits it | Drosophila melanogaster |
physiological function | requirement for rap gene function in photoreceptor R7, localization of rap gene activity, overview. Overactivity of Ras GTPase activating proteins or underactivity of Ras guanine exchange factors, among other possibilities might account for the limitation in the Ras pathway | Drosophila melanogaster |