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Literature summary for 3.6.5.2 extracted from

  • Mavromatakis, Y.E.; Tomlinson, A.
    The role of the small GTPase Rap in Drosophila R7 photoreceptor specification (2012), Proc. Natl. Acad. Sci. USA, 109, 3844-3849.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP + H2O Drosophila melanogaster
-
GDP + phosphate
-
?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster P08645
-
-

Source Tissue

Source Tissue Comment Organism Textmining
eye the enzyme is expressed in the R7 photoreceptor, localization study, overview Drosophila melanogaster
-
photoreceptor cell
-
Drosophila melanogaster
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + H2O
-
Drosophila melanogaster GDP + phosphate
-
?

Synonyms

Synonyms Comment Organism
RAP
-
Drosophila melanogaster
small GTPase
-
Drosophila melanogaster

General Information

General Information Comment Organism
evolution the enzyme belongs to the Ras superfamily Drosophila melanogaster
metabolism photoreceptor R7 is specified by the combined actions of the receptor tyrosine kinase (RTK) and Notch (N) signaling pathways. These pathways interact in a complex manner that includes antagonistic effects on photoreceptor specification and involve the small GTPase Rap. RTK promotes the photoreceptor fate, whereas N inhibits it Drosophila melanogaster
physiological function requirement for rap gene function in photoreceptor R7, localization of rap gene activity, overview. Overactivity of Ras GTPase activating proteins or underactivity of Ras guanine exchange factors, among other possibilities might account for the limitation in the Ras pathway Drosophila melanogaster