Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.6.5.2 extracted from

  • Hatano, T.; Morigasaki, S.; Tatebe, H.; Ikeda, K.; Shiozaki, K.
    Fission yeast Ryh1 GTPase activates TOR Complex 2 in response to glucose (2015), Cell Cycle, 14, 848-856.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.6.5.2

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Schizosaccharomyces pombe
-
-
-

Synonyms

Synonyms Comment Organism
Ryh1
-
 Schizosaccharomyces pombe
Ryh1 GTPase
-
 Schizosaccharomyces pombe

General Information

General Information Comment Organism
evolution enzyme Ryh1 belongs to the Rab-family GTPases Schizosaccharomyces pombe
physiological function the enzyme Ryh1 activates the target of rapamycin complex 2, TORC2, a protein kinase complex that is required for the TORC2-Gad8 pathway, which is essential for growth under glucose-limited conditions. the nucleotide-binding state of Ryh1 is regulated in response to glucose mediating the nutrient signal to TORC2. In glucose-rich growth media, the GTP-bound form of Ryh1 induces TORC2-dependent phosphorylation of Gad8, a downstream target of TORC2 in fission yeast. Upon glucose deprivation, Ryh1 becomes inactive, which turns off the TORC2-Gad8 pathway. During glucose starvation, Gad8 phosphorylation by TORC2 gradually recovers independently of Ryh1, implying an additional TORC2 activator that is regulated negatively by glucose. The paired positive and negative regulatory mechanisms may allow fine-tuning of the TORC2-Gad8 pathway Schizosaccharomyces pombe