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Literature summary for 3.6.5.2 extracted from

  • Na, R.H.; Zhu, G.H.; Luo, J.X.; Meng, X.J.; Cui, L.; Peng, H.J.; Chen, X.G.; Gomez-Cambronero, J.
    Enzymatically active Rho and Rac small-GTPases are involved in the establishment of the vacuolar membrane after Toxoplasma gondii invasion of host cells (2013), BMC Microbiol., 13, 125.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
additional information the recruited CFP-tagged RhoA on the parasitophorous vacuole membrane cannot be activated by epithelial growth factor and no translocation is observed, unlike the unassociated RhoA in the host cell cytosol that migrates to the cell membrane towards the epithelial growth factor activation spot Chlorocebus sabaeus

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information RhoA and Rac1 GTPases from the host cell accumulate on the parasitophorous vacuole membrane, PVM, regardless of the virulence of the Toxoplasma gondii strains after invasion, and this accumulation is dependent on their GTPase activity. The decisive domains for the RhoA accumulation on the PVM include the GTP/Mg2+ binding site, the mDia effector interaction site, the G1 box, the G2 box and the G5 box, respectively, which are related to the binding of GTP for enzymatic activity and mDia for the regulation of microtubules. The recruited RhoA on the PVM is in the GTP-bound active form Chlorocebus sabaeus
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additional information RhoA and Rac1 GTPases from the host cell accumulate on the parasitophorous vacuole membrane, PVM, regardless of the virulence of the Toxoplasma gondii strains after invasion, and this accumulation is dependent on their GTPase activity. The recruited Rac1 on the PVM is in the GTP-bound active form Chlorocebus sabaeus
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Organism

Organism UniProt Comment Textmining
Chlorocebus sabaeus A0A0D9RRD7 RhoA GTPase
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Chlorocebus sabaeus A0A0D9RYP7 Rac1 GTPase
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Source Tissue

Source Tissue Comment Organism Textmining
COS-7 cell
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 Chlorocebus sabaeus
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Synonyms

Synonyms Comment Organism
Rac1
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 Chlorocebus sabaeus
RhoA
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 Chlorocebus sabaeus
small-GTPase
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 Chlorocebus sabaeus

General Information

General Information Comment Organism
additional information real-time micrography of Toxoplasma gondii tachyzoites invading COS-7 cells overexpressing CFP-RhoA shows that this GTPase is recruited to the parasitophorous vacuole membrane at the very beginning of the invasion through the host cell membrane or from the cytosol Chlorocebus sabaeus